Myeloma tumor satellite DNA: A role in ribosomal RNA synthesis

Leonard J. Greenberg; Jonathan W. Uhr

doi:10.1016/S0006-291X(67)80018-4

Myeloma tumor satellite DNA: A role in ribosomal RNA synthesis

Leonard J. Greenberg, Jonathan W. Uhr

Immunology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The data in the present study is consistent with the concept of duplicated adjacent stretches of DNA coding for 16 and 28 S ribosomal RNA. The four-fold increase in hybrid formation between 16 S RNA and satellite DNA strongly suggests that satellite DNA codes for this RNA. The capacity for both DNA's to form hybrids with respect to 28 S RNA could mean that the DNA stretches coding for 28 S RNA are adjacent to those coding for 16 S RNA but are of slightly higher buoyant density. 10 S RNA appears to be coded for by the major band DNA only.

Original language	English (US)
Pages (from-to)	523-528
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	27
Issue number	5
DOIs	https://doi.org/10.1016/S0006-291X(67)80018-4
State	Published - Jun 9 1967

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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title = "Myeloma tumor satellite DNA: A role in ribosomal RNA synthesis",

abstract = "The data in the present study is consistent with the concept of duplicated adjacent stretches of DNA coding for 16 and 28 S ribosomal RNA. The four-fold increase in hybrid formation between 16 S RNA and satellite DNA strongly suggests that satellite DNA codes for this RNA. The capacity for both DNA's to form hybrids with respect to 28 S RNA could mean that the DNA stretches coding for 28 S RNA are adjacent to those coding for 16 S RNA but are of slightly higher buoyant density. 10 S RNA appears to be coded for by the major band DNA only.",

author = "Greenberg, {Leonard J.} and Uhr, {Jonathan W.}",

note = "Funding Information: * This work was supported by grant U-1647 of the Health Research Council of The City of New York, by USPHS grant AI-O1821-10 and by the Commission on Immunization of the Armed Forces Epidemiological Board, and by the Office of The Surgeon General, Department of the Army, Washington, D.C.",

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T1 - Myeloma tumor satellite DNA

T2 - A role in ribosomal RNA synthesis

AU - Greenberg, Leonard J.

AU - Uhr, Jonathan W.

N1 - Funding Information: * This work was supported by grant U-1647 of the Health Research Council of The City of New York, by USPHS grant AI-O1821-10 and by the Commission on Immunization of the Armed Forces Epidemiological Board, and by the Office of The Surgeon General, Department of the Army, Washington, D.C.

PY - 1967/6/9

Y1 - 1967/6/9

N2 - The data in the present study is consistent with the concept of duplicated adjacent stretches of DNA coding for 16 and 28 S ribosomal RNA. The four-fold increase in hybrid formation between 16 S RNA and satellite DNA strongly suggests that satellite DNA codes for this RNA. The capacity for both DNA's to form hybrids with respect to 28 S RNA could mean that the DNA stretches coding for 28 S RNA are adjacent to those coding for 16 S RNA but are of slightly higher buoyant density. 10 S RNA appears to be coded for by the major band DNA only.

AB - The data in the present study is consistent with the concept of duplicated adjacent stretches of DNA coding for 16 and 28 S ribosomal RNA. The four-fold increase in hybrid formation between 16 S RNA and satellite DNA strongly suggests that satellite DNA codes for this RNA. The capacity for both DNA's to form hybrids with respect to 28 S RNA could mean that the DNA stretches coding for 28 S RNA are adjacent to those coding for 16 S RNA but are of slightly higher buoyant density. 10 S RNA appears to be coded for by the major band DNA only.

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Myeloma tumor satellite DNA: A role in ribosomal RNA synthesis

Abstract

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