Abstract
To test the hypothesis that carnitine is decreased in the myocardial tissue of patients with end-stage congestive heart failure (CHF), left ventricular myocardial carnitine was measured in 51 patients undergoing orthotopic cardiac transplantation. The study group included patients with idiopathic dilated cardiomyopathy, coronary artery disease, myocarditis and rheumatic heart disease. Myocardial carnitine varied in different cardiac chambers. In normal control hearts, the left and right ventricular total carnitine was similar, but the ventricles had higher levels than the atria (p < 0.005); in 30 hearts in CHF, the left ventricular total carnitine was higher than in the right ventricle (p < 0.001) and both ventricles had higher total carnitine than the atria (p < 0.005). Only 7 of 51 patients with CHF had low myocardial carnitine, whereas plasma carnitine was elevated in all diagnostic groups of end-stage CHF studied.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 56-60 |
| Number of pages | 5 |
| Journal | The American Journal of Cardiology |
| Volume | 64 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 1 1989 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Myocardial carnitine in end-stage congestive heart failure. / Pierpont, Mary Ella M; Judd, Dianne; Goldenberg, Irvin F.; Ring, W. Steves; Olivari, Maria Teresa; Pierpont, Gordon L.
In: The American Journal of Cardiology, Vol. 64, No. 1, 01.07.1989, p. 56-60.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Myocardial carnitine in end-stage congestive heart failure
AU - Pierpont, Mary Ella M
AU - Judd, Dianne
AU - Goldenberg, Irvin F.
AU - Ring, W. Steves
AU - Olivari, Maria Teresa
AU - Pierpont, Gordon L.
PY - 1989/7/1
Y1 - 1989/7/1
N2 - To test the hypothesis that carnitine is decreased in the myocardial tissue of patients with end-stage congestive heart failure (CHF), left ventricular myocardial carnitine was measured in 51 patients undergoing orthotopic cardiac transplantation. The study group included patients with idiopathic dilated cardiomyopathy, coronary artery disease, myocarditis and rheumatic heart disease. Myocardial carnitine varied in different cardiac chambers. In normal control hearts, the left and right ventricular total carnitine was similar, but the ventricles had higher levels than the atria (p < 0.005); in 30 hearts in CHF, the left ventricular total carnitine was higher than in the right ventricle (p < 0.001) and both ventricles had higher total carnitine than the atria (p < 0.005). Only 7 of 51 patients with CHF had low myocardial carnitine, whereas plasma carnitine was elevated in all diagnostic groups of end-stage CHF studied.
AB - To test the hypothesis that carnitine is decreased in the myocardial tissue of patients with end-stage congestive heart failure (CHF), left ventricular myocardial carnitine was measured in 51 patients undergoing orthotopic cardiac transplantation. The study group included patients with idiopathic dilated cardiomyopathy, coronary artery disease, myocarditis and rheumatic heart disease. Myocardial carnitine varied in different cardiac chambers. In normal control hearts, the left and right ventricular total carnitine was similar, but the ventricles had higher levels than the atria (p < 0.005); in 30 hearts in CHF, the left ventricular total carnitine was higher than in the right ventricle (p < 0.001) and both ventricles had higher total carnitine than the atria (p < 0.005). Only 7 of 51 patients with CHF had low myocardial carnitine, whereas plasma carnitine was elevated in all diagnostic groups of end-stage CHF studied.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024336787&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(89)90653-X
DO - 10.1016/0002-9149(89)90653-X
M3 - Article
C2 - 2662734
AN - SCOPUS:0024336787
VL - 64
SP - 56
EP - 60
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 1
ER -