Myocardial carnitine in end-stage congestive heart failure

Mary Ella M Pierpont, Dianne Judd, Irvin F. Goldenberg, W. Steves Ring, Maria Teresa Olivari, Gordon L. Pierpont

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

To test the hypothesis that carnitine is decreased in the myocardial tissue of patients with end-stage congestive heart failure (CHF), left ventricular myocardial carnitine was measured in 51 patients undergoing orthotopic cardiac transplantation. The study group included patients with idiopathic dilated cardiomyopathy, coronary artery disease, myocarditis and rheumatic heart disease. Myocardial carnitine varied in different cardiac chambers. In normal control hearts, the left and right ventricular total carnitine was similar, but the ventricles had higher levels than the atria (p < 0.005); in 30 hearts in CHF, the left ventricular total carnitine was higher than in the right ventricle (p < 0.001) and both ventricles had higher total carnitine than the atria (p < 0.005). Only 7 of 51 patients with CHF had low myocardial carnitine, whereas plasma carnitine was elevated in all diagnostic groups of end-stage CHF studied.

Original languageEnglish (US)
Pages (from-to)56-60
Number of pages5
JournalThe American Journal of Cardiology
Volume64
Issue number1
DOIs
StatePublished - Jul 1 1989

Fingerprint

Carnitine
Heart Failure
Rheumatic Heart Disease
Myocarditis
Dilated Cardiomyopathy
Heart Transplantation
Heart Ventricles
Coronary Artery Disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Pierpont, M. E. M., Judd, D., Goldenberg, I. F., Ring, W. S., Olivari, M. T., & Pierpont, G. L. (1989). Myocardial carnitine in end-stage congestive heart failure. The American Journal of Cardiology, 64(1), 56-60. https://doi.org/10.1016/0002-9149(89)90653-X

Myocardial carnitine in end-stage congestive heart failure. / Pierpont, Mary Ella M; Judd, Dianne; Goldenberg, Irvin F.; Ring, W. Steves; Olivari, Maria Teresa; Pierpont, Gordon L.

In: The American Journal of Cardiology, Vol. 64, No. 1, 01.07.1989, p. 56-60.

Research output: Contribution to journalArticle

Pierpont, MEM, Judd, D, Goldenberg, IF, Ring, WS, Olivari, MT & Pierpont, GL 1989, 'Myocardial carnitine in end-stage congestive heart failure', The American Journal of Cardiology, vol. 64, no. 1, pp. 56-60. https://doi.org/10.1016/0002-9149(89)90653-X
Pierpont, Mary Ella M ; Judd, Dianne ; Goldenberg, Irvin F. ; Ring, W. Steves ; Olivari, Maria Teresa ; Pierpont, Gordon L. / Myocardial carnitine in end-stage congestive heart failure. In: The American Journal of Cardiology. 1989 ; Vol. 64, No. 1. pp. 56-60.
@article{7a4a4ae97c8041fbac3f4d6f3c405b45,
title = "Myocardial carnitine in end-stage congestive heart failure",
abstract = "To test the hypothesis that carnitine is decreased in the myocardial tissue of patients with end-stage congestive heart failure (CHF), left ventricular myocardial carnitine was measured in 51 patients undergoing orthotopic cardiac transplantation. The study group included patients with idiopathic dilated cardiomyopathy, coronary artery disease, myocarditis and rheumatic heart disease. Myocardial carnitine varied in different cardiac chambers. In normal control hearts, the left and right ventricular total carnitine was similar, but the ventricles had higher levels than the atria (p < 0.005); in 30 hearts in CHF, the left ventricular total carnitine was higher than in the right ventricle (p < 0.001) and both ventricles had higher total carnitine than the atria (p < 0.005). Only 7 of 51 patients with CHF had low myocardial carnitine, whereas plasma carnitine was elevated in all diagnostic groups of end-stage CHF studied.",
author = "Pierpont, {Mary Ella M} and Dianne Judd and Goldenberg, {Irvin F.} and Ring, {W. Steves} and Olivari, {Maria Teresa} and Pierpont, {Gordon L.}",
year = "1989",
month = "7",
day = "1",
doi = "10.1016/0002-9149(89)90653-X",
language = "English (US)",
volume = "64",
pages = "56--60",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Myocardial carnitine in end-stage congestive heart failure

AU - Pierpont, Mary Ella M

AU - Judd, Dianne

AU - Goldenberg, Irvin F.

AU - Ring, W. Steves

AU - Olivari, Maria Teresa

AU - Pierpont, Gordon L.

PY - 1989/7/1

Y1 - 1989/7/1

N2 - To test the hypothesis that carnitine is decreased in the myocardial tissue of patients with end-stage congestive heart failure (CHF), left ventricular myocardial carnitine was measured in 51 patients undergoing orthotopic cardiac transplantation. The study group included patients with idiopathic dilated cardiomyopathy, coronary artery disease, myocarditis and rheumatic heart disease. Myocardial carnitine varied in different cardiac chambers. In normal control hearts, the left and right ventricular total carnitine was similar, but the ventricles had higher levels than the atria (p < 0.005); in 30 hearts in CHF, the left ventricular total carnitine was higher than in the right ventricle (p < 0.001) and both ventricles had higher total carnitine than the atria (p < 0.005). Only 7 of 51 patients with CHF had low myocardial carnitine, whereas plasma carnitine was elevated in all diagnostic groups of end-stage CHF studied.

AB - To test the hypothesis that carnitine is decreased in the myocardial tissue of patients with end-stage congestive heart failure (CHF), left ventricular myocardial carnitine was measured in 51 patients undergoing orthotopic cardiac transplantation. The study group included patients with idiopathic dilated cardiomyopathy, coronary artery disease, myocarditis and rheumatic heart disease. Myocardial carnitine varied in different cardiac chambers. In normal control hearts, the left and right ventricular total carnitine was similar, but the ventricles had higher levels than the atria (p < 0.005); in 30 hearts in CHF, the left ventricular total carnitine was higher than in the right ventricle (p < 0.001) and both ventricles had higher total carnitine than the atria (p < 0.005). Only 7 of 51 patients with CHF had low myocardial carnitine, whereas plasma carnitine was elevated in all diagnostic groups of end-stage CHF studied.

UR - http://www.scopus.com/inward/record.url?scp=0024336787&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024336787&partnerID=8YFLogxK

U2 - 10.1016/0002-9149(89)90653-X

DO - 10.1016/0002-9149(89)90653-X

M3 - Article

C2 - 2662734

AN - SCOPUS:0024336787

VL - 64

SP - 56

EP - 60

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 1

ER -