Myocardial dynamics during direct mechanical ventricular actuation of the fibrillating heart

Linda A. Feagins, Carrie K. Guill, Joseph P. Malone, George L. Anstadt, Daniel J. Nolan, Mark P. Anstadt

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Direct mechanical ventricular actuation (DMVA) is a method of non-blood contacting ventricular support. DMVA uses a pneumatically regulated, vacuum attached, flexible membrane for transfer of systolic and diastolic forces to the ventricular myocardium. The purpose of this study was to assess myocardial dynamics when DMVA supported the heart during ventricular fibrillation (VF) arrest. Adult canine (n=10) underwent left thoracotomy and were instrumented for monitoring ventricular hemodynamics. Left and right ventriculograms were obtained using cineangiography during: a) sinus rhythm (SR), and b) VF with DMVA providing total circulatory support. Images were then digitized and computer analyzed to assess valve function, pump performance, as well as RV and LV dynamics. Decreased end-diastolic volumes (*33%) were compensated by decreased end-systolic volumes (*75%), thereby maintaining stroke volume and increasing ejection fraction (*30%) during DMVA vs. SR, (*p<0.05). Marked increases in diastolic filling rates documented DMVA's diastolic effect during VF (111 vs. 233 milliseconds, DMVA vs. SR, p=0.003). Cartesianal coordinate analysis of wall motion dynamics revealed characteristic configurational changes during DMVA. These findings demonstrate DMVA's ability to provide diastolic actuation. Diastolic actuation addresses the rate-limited, passive ventricular filling inherent to direct cardiac compression (DCC) when supporting the VF arrested heart. Studies are needed to compare diastolic assist and systolic wall-motion influences during DMVA and DCC support of the failing heart.

Original languageEnglish (US)
Pages (from-to)168
Number of pages1
JournalASAIO Journal
Volume46
Issue number2
StatePublished - Mar 2000

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Ventricular Fibrillation
Hemodynamics
Cineangiography
Compaction
Thoracotomy
Vacuum
Pumps
Stroke Volume
Membranes
Canidae
Myocardium
Monitoring

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering

Cite this

Feagins, L. A., Guill, C. K., Malone, J. P., Anstadt, G. L., Nolan, D. J., & Anstadt, M. P. (2000). Myocardial dynamics during direct mechanical ventricular actuation of the fibrillating heart. ASAIO Journal, 46(2), 168.

Myocardial dynamics during direct mechanical ventricular actuation of the fibrillating heart. / Feagins, Linda A.; Guill, Carrie K.; Malone, Joseph P.; Anstadt, George L.; Nolan, Daniel J.; Anstadt, Mark P.

In: ASAIO Journal, Vol. 46, No. 2, 03.2000, p. 168.

Research output: Contribution to journalArticle

Feagins, LA, Guill, CK, Malone, JP, Anstadt, GL, Nolan, DJ & Anstadt, MP 2000, 'Myocardial dynamics during direct mechanical ventricular actuation of the fibrillating heart', ASAIO Journal, vol. 46, no. 2, pp. 168.
Feagins LA, Guill CK, Malone JP, Anstadt GL, Nolan DJ, Anstadt MP. Myocardial dynamics during direct mechanical ventricular actuation of the fibrillating heart. ASAIO Journal. 2000 Mar;46(2):168.
Feagins, Linda A. ; Guill, Carrie K. ; Malone, Joseph P. ; Anstadt, George L. ; Nolan, Daniel J. ; Anstadt, Mark P. / Myocardial dynamics during direct mechanical ventricular actuation of the fibrillating heart. In: ASAIO Journal. 2000 ; Vol. 46, No. 2. pp. 168.
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