Myocardial infarct size determined by computed transmission tomography in canine infarcts of various ages and in the presence of coronary reperfusion

Robert A. Slutsky, Wallace W. Peck, G. B.John Mancini, Robert F. Mattrey, Charles B. Higgins

Research output: Contribution to journalArticle

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Abstract

Thirty-one dogs underwent in vivo scanning with computed transmission tomography; 15 dogs were studied within 7 days (mean 4) after coronary occlusion, 10 dogs 21 to 25 days (mean 28) after occlusion and 6 dogs 4 days after coronary reperfusion of a 2 to 3 hour coronary ligation. Ungated scans (1 cm in depth) of the left ventricle were obtained from apex to base to determine infarct size. In all animals with documented (postmortem) infarction (n = 26), contrast medium caused delayed enhancement of the entire infarct or the periphery of the infarct. Infarct size was calculated from scans showing contrast enhancement of the infarct. Infarct size was also determined from the postmortem heart using histochemical morphometry (nitroblue tetrazolium) and then compared with infarct size derived from tomography using the outer margin of the contrast-enhanced periphery of the infarct as the border of the infarct. Infarct size calculated by the tomographic technique (excluding the animals without an infarct) correlated well with infarct size determined at autopsy (r = 0.90, p < 0.001). The tomographic estimate (18.2 ± 11.3 g) of infarct size was similar to autopsy values (18.6 ± 11.8 g, p = NS). Thus, ungated computed transmission tomographic imaging of the heart can reliably estimate infarct size in a variety of potential clinical circumstances, particularly when the area of rim enhancement of the infarct is included within the presumed infarct region.

Original languageEnglish (US)
Pages (from-to)138-142
Number of pages5
JournalJournal of the American College of Cardiology
Volume3
Issue number1
DOIs
StatePublished - Jan 1 1984

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Myocardial Reperfusion
X Ray Computed Tomography
Canidae
Myocardial Infarction
Dogs
Autopsy
Nitroblue Tetrazolium
Coronary Occlusion
Infarction
Contrast Media
Heart Ventricles
Ligation
Tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Myocardial infarct size determined by computed transmission tomography in canine infarcts of various ages and in the presence of coronary reperfusion. / Slutsky, Robert A.; Peck, Wallace W.; Mancini, G. B.John; Mattrey, Robert F.; Higgins, Charles B.

In: Journal of the American College of Cardiology, Vol. 3, No. 1, 01.01.1984, p. 138-142.

Research output: Contribution to journalArticle

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