Myocyte injury along myofibers in left ventricular remodeling after myocardial infarction

Yoichiro Kusakari, Chun Yang Xiao, Nathan Himes, Stuart D. Kinsella, Masaya Takahashi, Anthony Rosenzweig, Takashi Matsui

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Left ventricular (LV) remodeling following myocardial infarction (MI) is considered to contribute to cardiac dysfunction. Though myofiber organization is a key component of cardiac structure, functional and anatomical features of injured myofiber during LV remodeling have not been fully defined. We investigated myocyte injury after acute MI in a mouse model. Mice were subjected to surgical coronary occlusionyreperfusion by left anterior descending coronary artery (LAD) ligation and examined at 1 week and 4 weeks post-MI. Magnetic resonance imaging (MRI) analysis demonstrated a significant decrease in systolic regional wall thickening (WT) in the border and remote zones at 4 weeks post-MI compared to that at 1 week post-MI (-86% in border zone, P<0.05, and -77% in remote zone, P<0.05). Histological assays demonstrated that a broad fibrotic scar extended from the initial infarct zone to the remote zone along midcircumferential myofibers. Of particular note was the fact that no fibrosis was found in longitudinal myofibers in the epi- and endomyocardium. This pattern of the scar formation coincided with the helical ventricular myocardial band (HVMB) model, introduced by Torrent-Guasp. MRI analysis demonstrated that the extension of the fibrotic scar along the band might account for the progression in cardiac dysfunction during LV remodeling.

Original languageEnglish (US)
Pages (from-to)951-955
Number of pages5
JournalInteractive Cardiovascular and Thoracic Surgery
Volume9
Issue number6
DOIs
StatePublished - Dec 2009

Fingerprint

Ventricular Remodeling
Muscle Cells
Myocardial Infarction
Wounds and Injuries
Cicatrix
Magnetic Resonance Imaging
Ligation
Coronary Vessels
Fibrosis

Keywords

  • Animals
  • Muscle fibers
  • Ventricular function
  • Ventricular remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery

Cite this

Myocyte injury along myofibers in left ventricular remodeling after myocardial infarction. / Kusakari, Yoichiro; Xiao, Chun Yang; Himes, Nathan; Kinsella, Stuart D.; Takahashi, Masaya; Rosenzweig, Anthony; Matsui, Takashi.

In: Interactive Cardiovascular and Thoracic Surgery, Vol. 9, No. 6, 12.2009, p. 951-955.

Research output: Contribution to journalArticle

Kusakari, Yoichiro ; Xiao, Chun Yang ; Himes, Nathan ; Kinsella, Stuart D. ; Takahashi, Masaya ; Rosenzweig, Anthony ; Matsui, Takashi. / Myocyte injury along myofibers in left ventricular remodeling after myocardial infarction. In: Interactive Cardiovascular and Thoracic Surgery. 2009 ; Vol. 9, No. 6. pp. 951-955.
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