N-linked analogs of retinoid O-glucuronides: potential cancer chemopreventive/chemotherapeutic agents

M. J. Robarge, J. J. Repa, K. K. Hanson, S. Seth, M. Clagett-Dame, H. Abou-Issa, R. W. Curley

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Glucuronide metabolites of retinoic acid (RA) and its analogs have been suggested to be active cancer chemopreventive/chemotherapeutic metabolites of the parent molecule. The glucuronide of RA is relatively unstable, thus we prepared N-linked glycoside analogs of RA that are nonsubstrates for β-glucuronidase in efforts to improve efficacy. The synthesis and biological activity of the analogs are reported.

Original languageEnglish (US)
Pages (from-to)2117-2122
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number17
DOIs
StatePublished - Sep 8 1994

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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