Neoplastic Meningitis and Paraneoplastic Syndromes

Sangam Kanekar, Thomas Zacharia, Amit Agarwal

Research output: Contribution to journalReview articlepeer-review

Abstract

Neoplastic meningitis (NM) and paraneoplastic syndromes (PNSs) are a rare group of disorders present in patients with cancer. Clinical diagnosis of these conditions is challenging, and imaging and laboratory analysis play a significant role in diagnosing. Diagnosis of NM largely depends on documenting circulating tumor cells in the cerebrospinal fluid (CSF) and/or leptomeningeal and nodular enhancement on contrast-enhanced MR imaging of the brain or axial spine. PNSs encompass a variety of symptoms or syndromes. Paraneoplastic neuronal disorder diagnosis requires a multidimensional approach, high clinical suspicion, CSF and serum examination, and imaging. Neuroimaging is an integral part in the evaluation.

Original languageEnglish (US)
Pages (from-to)409-423
Number of pages15
JournalRadiologic Clinics of North America
Volume59
Issue number3
DOIs
StatePublished - May 1 2021
Externally publishedYes

Keywords

  • Anti-NMDAR encephalitis
  • Leptomeningeal metastasis
  • Limbic encephalitis
  • Neoplastic meningitis
  • Paraneoplastic syndromes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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