NESdb: A database of NES-containing CRM1 cargoes

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

The leucine-rich nuclear export signal (NES) is the only known class of targeting signal that directs macromolecules out of the cell nucleus. NESs are short stretches of 8-15 amino acids with regularly spaced hydrophobic residues that bind the export karyopherin CRM1. NES-containing proteins are involved in numerous cellular and disease processes. We compiled a database named NESdb that contains 221 NES-containing CRM1 cargoes that were manually curated from the published literature. Each NESdb entry is annotated with information about sequence and structure of both the NES and the cargo protein, as well as information about experimental evidence of NES-mapping and CRM1- mediated nuclear export. NESdb will be updated regularly and will serve as an important resource for nuclear export signals. NESdb is freely available to nonprofit organizations at http://prodata.swmed.edu/LRNes.

Original languageEnglish (US)
Pages (from-to)3673-3676
Number of pages4
JournalMolecular Biology of the Cell
Volume23
Issue number18
DOIs
StatePublished - Sep 15 2012

Fingerprint

Nuclear Export Signals
Databases
Nonprofit Organizations
Karyopherins
Cell Nucleus Active Transport
Cell Nucleus
Leucine
Proteins
Amino Acids

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

NESdb : A database of NES-containing CRM1 cargoes. / Xu, Darui; Grishin, Nick V.; Chook, Yuh Min.

In: Molecular Biology of the Cell, Vol. 23, No. 18, 15.09.2012, p. 3673-3676.

Research output: Contribution to journalArticle

@article{304299001a9c4debbb45380872b3e86c,
title = "NESdb: A database of NES-containing CRM1 cargoes",
abstract = "The leucine-rich nuclear export signal (NES) is the only known class of targeting signal that directs macromolecules out of the cell nucleus. NESs are short stretches of 8-15 amino acids with regularly spaced hydrophobic residues that bind the export karyopherin CRM1. NES-containing proteins are involved in numerous cellular and disease processes. We compiled a database named NESdb that contains 221 NES-containing CRM1 cargoes that were manually curated from the published literature. Each NESdb entry is annotated with information about sequence and structure of both the NES and the cargo protein, as well as information about experimental evidence of NES-mapping and CRM1- mediated nuclear export. NESdb will be updated regularly and will serve as an important resource for nuclear export signals. NESdb is freely available to nonprofit organizations at http://prodata.swmed.edu/LRNes.",
author = "Darui Xu and Grishin, {Nick V.} and Chook, {Yuh Min}",
year = "2012",
month = "9",
day = "15",
doi = "10.1091/mbc.E12-01-0045",
language = "English (US)",
volume = "23",
pages = "3673--3676",
journal = "Molecular Biology of the Cell",
issn = "1059-1524",
publisher = "American Society for Cell Biology",
number = "18",

}

TY - JOUR

T1 - NESdb

T2 - A database of NES-containing CRM1 cargoes

AU - Xu, Darui

AU - Grishin, Nick V.

AU - Chook, Yuh Min

PY - 2012/9/15

Y1 - 2012/9/15

N2 - The leucine-rich nuclear export signal (NES) is the only known class of targeting signal that directs macromolecules out of the cell nucleus. NESs are short stretches of 8-15 amino acids with regularly spaced hydrophobic residues that bind the export karyopherin CRM1. NES-containing proteins are involved in numerous cellular and disease processes. We compiled a database named NESdb that contains 221 NES-containing CRM1 cargoes that were manually curated from the published literature. Each NESdb entry is annotated with information about sequence and structure of both the NES and the cargo protein, as well as information about experimental evidence of NES-mapping and CRM1- mediated nuclear export. NESdb will be updated regularly and will serve as an important resource for nuclear export signals. NESdb is freely available to nonprofit organizations at http://prodata.swmed.edu/LRNes.

AB - The leucine-rich nuclear export signal (NES) is the only known class of targeting signal that directs macromolecules out of the cell nucleus. NESs are short stretches of 8-15 amino acids with regularly spaced hydrophobic residues that bind the export karyopherin CRM1. NES-containing proteins are involved in numerous cellular and disease processes. We compiled a database named NESdb that contains 221 NES-containing CRM1 cargoes that were manually curated from the published literature. Each NESdb entry is annotated with information about sequence and structure of both the NES and the cargo protein, as well as information about experimental evidence of NES-mapping and CRM1- mediated nuclear export. NESdb will be updated regularly and will serve as an important resource for nuclear export signals. NESdb is freely available to nonprofit organizations at http://prodata.swmed.edu/LRNes.

UR - http://www.scopus.com/inward/record.url?scp=84866422549&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866422549&partnerID=8YFLogxK

U2 - 10.1091/mbc.E12-01-0045

DO - 10.1091/mbc.E12-01-0045

M3 - Article

C2 - 22833564

AN - SCOPUS:84866422549

VL - 23

SP - 3673

EP - 3676

JO - Molecular Biology of the Cell

JF - Molecular Biology of the Cell

SN - 1059-1524

IS - 18

ER -