Neural basis of reward anticipation and its genetic determinants

IMAGEN Consortium

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Dysfunctional reward processing is implicated in various mental disorders, including attention deficit hyperactivity disorder (ADHD) and addictions. Such impairments might involve different components of the reward process, including brain activity during reward anticipation. We examined brain nodes engaged by reward anticipation in 1,544 adolescents and identified a network containing a core striatal node and cortical nodes facilitating outcome prediction and response preparation. Distinct nodes and functional connections were preferentially associated with either adolescent hyperactivity or alcohol consumption, thus conveying specificity of reward processing to clinically relevant behavior. We observed associations between the striatal node, hyperactivity, and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila. Our data provide a neurobehavioral model explaining the heterogeneity of rewardrelated behaviors and generate a hypothesis accounting for their enduring nature.

Original languageEnglish (US)
Pages (from-to)3879-3884
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume113
Issue number14
DOIs
StatePublished - Apr 5 2016

Keywords

  • Dopamine receptor
  • FMRI
  • GWAS
  • Neural network
  • VPS4A

ASJC Scopus subject areas

  • General

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