Neural plasticity and functional recovery following cortical ischemie injury

Erik J. Plautz, Randolph J. Nudo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Stroke is a leading cause of persistent motor disability, but few effective treatments exist for application at chronic post-injury timepoints. An approach that combines rehabilitative training with cortical electrical stimulation was evaluated in a non-human primate model of cortical ischemic stroke. Results indicate that cortical stimulation plus rehabilitation enhanced motor recovery compared to rehabilitation alone. Functional mapping of the spared, peri-infarct motor cortex revealed expansions of motor representations related to the rehabilitative task, with greater expansions for subjects that underwent the combined therapy. It is concluded that electrical stimulation combined with rehabilitation enhanced plastic reorganization of the affected motor cortex, leading to superior behavioral recovery.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages4145-4148
Number of pages4
Volume7 VOLS
Publication statusPublished - 2005
Event2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 - Shanghai, China
Duration: Sep 1 2005Sep 4 2005

Other

Other2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
CountryChina
CityShanghai
Period9/1/059/4/05

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ASJC Scopus subject areas

  • Bioengineering

Cite this

Plautz, E. J., & Nudo, R. J. (2005). Neural plasticity and functional recovery following cortical ischemie injury. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 7 VOLS, pp. 4145-4148). [1615376]