Abstract
Epilepsy is a disorder of the central nervous system characterized by spontaneous recurrent seizures. Although current therapies exist to control the number and severity of clinical seizures, there are no pharmacological cures or disease-modifying treatments available. Use of transgenic mouse models has allowed an understanding of neural stem cells in their relation to epileptogenesis in mesial temporal lobe epilepsy. Further, with the significant discovery of factors necessary to reprogram adult somatic cell types into pluripotent stem cells, it has become possible to study monogenic epilepsy-in-a-dish using patient-derived neurons. This discovery along with some of the newest technological advances in recapitulating brain development in a dish has brought us closer than ever to a platform in which to study and understand the mechanisms of this disease. These technologies will be critical in understanding the mechanism of epileptogenesis and ultimately lead to improved therapies and precision medicine for patients with epilepsy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-8 |
| Number of pages | 8 |
| Journal | Cell and Tissue Research |
| DOIs | |
| State | Accepted/In press - Aug 22 2017 |
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Keywords
- Adult neurogenesis
- Epilepsy
- Neural stem cells
- Organoids
- Seizure
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology
- Cell Biology
Cite this
Neural stem cells and epilepsy : functional roles and disease-in-a-dish models. / Thodeson, Drew Michael; Brulet, Rebecca; Hsieh, Jenny.
In: Cell and Tissue Research, 22.08.2017, p. 1-8.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neural stem cells and epilepsy
T2 - functional roles and disease-in-a-dish models
AU - Thodeson, Drew Michael
AU - Brulet, Rebecca
AU - Hsieh, Jenny
PY - 2017/8/22
Y1 - 2017/8/22
N2 - Epilepsy is a disorder of the central nervous system characterized by spontaneous recurrent seizures. Although current therapies exist to control the number and severity of clinical seizures, there are no pharmacological cures or disease-modifying treatments available. Use of transgenic mouse models has allowed an understanding of neural stem cells in their relation to epileptogenesis in mesial temporal lobe epilepsy. Further, with the significant discovery of factors necessary to reprogram adult somatic cell types into pluripotent stem cells, it has become possible to study monogenic epilepsy-in-a-dish using patient-derived neurons. This discovery along with some of the newest technological advances in recapitulating brain development in a dish has brought us closer than ever to a platform in which to study and understand the mechanisms of this disease. These technologies will be critical in understanding the mechanism of epileptogenesis and ultimately lead to improved therapies and precision medicine for patients with epilepsy.
AB - Epilepsy is a disorder of the central nervous system characterized by spontaneous recurrent seizures. Although current therapies exist to control the number and severity of clinical seizures, there are no pharmacological cures or disease-modifying treatments available. Use of transgenic mouse models has allowed an understanding of neural stem cells in their relation to epileptogenesis in mesial temporal lobe epilepsy. Further, with the significant discovery of factors necessary to reprogram adult somatic cell types into pluripotent stem cells, it has become possible to study monogenic epilepsy-in-a-dish using patient-derived neurons. This discovery along with some of the newest technological advances in recapitulating brain development in a dish has brought us closer than ever to a platform in which to study and understand the mechanisms of this disease. These technologies will be critical in understanding the mechanism of epileptogenesis and ultimately lead to improved therapies and precision medicine for patients with epilepsy.
KW - Adult neurogenesis
KW - Epilepsy
KW - Neural stem cells
KW - Organoids
KW - Seizure
UR - http://www.scopus.com/inward/record.url?scp=85027875910&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85027875910&partnerID=8YFLogxK
U2 - 10.1007/s00441-017-2675-z
DO - 10.1007/s00441-017-2675-z
M3 - Article
C2 - 28831605
AN - SCOPUS:85027875910
SP - 1
EP - 8
JO - Cell and Tissue Research
JF - Cell and Tissue Research
SN - 0302-766X
ER -