Neural stem cells and epilepsy: functional roles and disease-in-a-dish models

Drew Michael Thodeson; Rebecca Brulet; Jenny Hsieh

doi:10.1007/s00441-017-2675-z

Neural stem cells and epilepsy: functional roles and disease-in-a-dish models

Drew Michael Thodeson, Rebecca Brulet, Jenny Hsieh

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Epilepsy is a disorder of the central nervous system characterized by spontaneous recurrent seizures. Although current therapies exist to control the number and severity of clinical seizures, there are no pharmacological cures or disease-modifying treatments available. Use of transgenic mouse models has allowed an understanding of neural stem cells in their relation to epileptogenesis in mesial temporal lobe epilepsy. Further, with the significant discovery of factors necessary to reprogram adult somatic cell types into pluripotent stem cells, it has become possible to study monogenic epilepsy-in-a-dish using patient-derived neurons. This discovery along with some of the newest technological advances in recapitulating brain development in a dish has brought us closer than ever to a platform in which to study and understand the mechanisms of this disease. These technologies will be critical in understanding the mechanism of epileptogenesis and ultimately lead to improved therapies and precision medicine for patients with epilepsy.

Original language	English (US)
Pages (from-to)	47-54
Number of pages	8
Journal	Cell and Tissue Research
Volume	371
Issue number	1
DOIs	https://doi.org/10.1007/s00441-017-2675-z
State	Published - Jan 1 2018

Keywords

Adult neurogenesis
Epilepsy
Neural stem cells
Organoids
Seizure

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology
Cell Biology

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title = "Neural stem cells and epilepsy: functional roles and disease-in-a-dish models",

abstract = "Epilepsy is a disorder of the central nervous system characterized by spontaneous recurrent seizures. Although current therapies exist to control the number and severity of clinical seizures, there are no pharmacological cures or disease-modifying treatments available. Use of transgenic mouse models has allowed an understanding of neural stem cells in their relation to epileptogenesis in mesial temporal lobe epilepsy. Further, with the significant discovery of factors necessary to reprogram adult somatic cell types into pluripotent stem cells, it has become possible to study monogenic epilepsy-in-a-dish using patient-derived neurons. This discovery along with some of the newest technological advances in recapitulating brain development in a dish has brought us closer than ever to a platform in which to study and understand the mechanisms of this disease. These technologies will be critical in understanding the mechanism of epileptogenesis and ultimately lead to improved therapies and precision medicine for patients with epilepsy.",

keywords = "Adult neurogenesis, Epilepsy, Neural stem cells, Organoids, Seizure",

author = "Thodeson, {Drew Michael} and Rebecca Brulet and Jenny Hsieh",

note = "Funding Information: We thank Jose Cabrera for help with the figures. This work was supported by grants from the National Institute of Health (NIH) R01NS081203, R01NS089770, R01NS093992 and K02AG041815 to J.H., Department of Defense W81XWH-15-1 to J.H., American Heart Association 15GRNT25750034 to J.H., a grant from the Texas Institute for Brain Injury and Repair to J.H. and an award from the National Center for Advancing Translational Sciences (NIH) UL1TR001105 to D.T. Funding Information: Acknowledgements We thank Jose Cabrera for help with the figures. This work was supported by grants from the National Institute of Health (NIH) R01NS081203, R01NS089770, R01NS093992 and K02AG041815 to J.H., Department of Defense W81XWH-15-1 to J.H., American Heart Association 15GRNT25750034 to J.H., a grant from the Texas Institute for Brain Injury and Repair to J.H. and an award from the National Center for Advancing Translational Sciences (NIH) UL1TR001105 to D.T. Publisher Copyright: {\textcopyright} 2017, Springer-Verlag GmbH Germany.",

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doi = "10.1007/s00441-017-2675-z",

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AU - Thodeson, Drew Michael

AU - Brulet, Rebecca

AU - Hsieh, Jenny

N1 - Funding Information: We thank Jose Cabrera for help with the figures. This work was supported by grants from the National Institute of Health (NIH) R01NS081203, R01NS089770, R01NS093992 and K02AG041815 to J.H., Department of Defense W81XWH-15-1 to J.H., American Heart Association 15GRNT25750034 to J.H., a grant from the Texas Institute for Brain Injury and Repair to J.H. and an award from the National Center for Advancing Translational Sciences (NIH) UL1TR001105 to D.T. Funding Information: Acknowledgements We thank Jose Cabrera for help with the figures. This work was supported by grants from the National Institute of Health (NIH) R01NS081203, R01NS089770, R01NS093992 and K02AG041815 to J.H., Department of Defense W81XWH-15-1 to J.H., American Heart Association 15GRNT25750034 to J.H., a grant from the Texas Institute for Brain Injury and Repair to J.H. and an award from the National Center for Advancing Translational Sciences (NIH) UL1TR001105 to D.T. Publisher Copyright: © 2017, Springer-Verlag GmbH Germany.

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N2 - Epilepsy is a disorder of the central nervous system characterized by spontaneous recurrent seizures. Although current therapies exist to control the number and severity of clinical seizures, there are no pharmacological cures or disease-modifying treatments available. Use of transgenic mouse models has allowed an understanding of neural stem cells in their relation to epileptogenesis in mesial temporal lobe epilepsy. Further, with the significant discovery of factors necessary to reprogram adult somatic cell types into pluripotent stem cells, it has become possible to study monogenic epilepsy-in-a-dish using patient-derived neurons. This discovery along with some of the newest technological advances in recapitulating brain development in a dish has brought us closer than ever to a platform in which to study and understand the mechanisms of this disease. These technologies will be critical in understanding the mechanism of epileptogenesis and ultimately lead to improved therapies and precision medicine for patients with epilepsy.

AB - Epilepsy is a disorder of the central nervous system characterized by spontaneous recurrent seizures. Although current therapies exist to control the number and severity of clinical seizures, there are no pharmacological cures or disease-modifying treatments available. Use of transgenic mouse models has allowed an understanding of neural stem cells in their relation to epileptogenesis in mesial temporal lobe epilepsy. Further, with the significant discovery of factors necessary to reprogram adult somatic cell types into pluripotent stem cells, it has become possible to study monogenic epilepsy-in-a-dish using patient-derived neurons. This discovery along with some of the newest technological advances in recapitulating brain development in a dish has brought us closer than ever to a platform in which to study and understand the mechanisms of this disease. These technologies will be critical in understanding the mechanism of epileptogenesis and ultimately lead to improved therapies and precision medicine for patients with epilepsy.

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KW - Neural stem cells

KW - Organoids

KW - Seizure

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JO - Cell and Tissue Research

JF - Cell and Tissue Research

SN - 0302-766X

IS - 1

ER -

Neural stem cells and epilepsy: functional roles and disease-in-a-dish models

Abstract

Keywords

ASJC Scopus subject areas

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