Neural stem cells and epilepsy: functional roles and disease-in-a-dish models

Drew Michael Thodeson, Rebecca Brulet, Jenny Hsieh

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Epilepsy is a disorder of the central nervous system characterized by spontaneous recurrent seizures. Although current therapies exist to control the number and severity of clinical seizures, there are no pharmacological cures or disease-modifying treatments available. Use of transgenic mouse models has allowed an understanding of neural stem cells in their relation to epileptogenesis in mesial temporal lobe epilepsy. Further, with the significant discovery of factors necessary to reprogram adult somatic cell types into pluripotent stem cells, it has become possible to study monogenic epilepsy-in-a-dish using patient-derived neurons. This discovery along with some of the newest technological advances in recapitulating brain development in a dish has brought us closer than ever to a platform in which to study and understand the mechanisms of this disease. These technologies will be critical in understanding the mechanism of epileptogenesis and ultimately lead to improved therapies and precision medicine for patients with epilepsy.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalCell and Tissue Research
DOIs
StateAccepted/In press - Aug 22 2017

Fingerprint

Neural Stem Cells
Epilepsy
Seizures
Pluripotent Stem Cells
Precision Medicine
Temporal Lobe Epilepsy
Central Nervous System Diseases
Transgenic Mice
Therapeutics
Pharmacology
Technology
Neurons
Brain

Keywords

  • Adult neurogenesis
  • Epilepsy
  • Neural stem cells
  • Organoids
  • Seizure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

Cite this

Neural stem cells and epilepsy : functional roles and disease-in-a-dish models. / Thodeson, Drew Michael; Brulet, Rebecca; Hsieh, Jenny.

In: Cell and Tissue Research, 22.08.2017, p. 1-8.

Research output: Contribution to journalArticle

Thodeson, Drew Michael ; Brulet, Rebecca ; Hsieh, Jenny. / Neural stem cells and epilepsy : functional roles and disease-in-a-dish models. In: Cell and Tissue Research. 2017 ; pp. 1-8.
@article{39475bfadb88465aae22c84ea136dd41,
title = "Neural stem cells and epilepsy: functional roles and disease-in-a-dish models",
abstract = "Epilepsy is a disorder of the central nervous system characterized by spontaneous recurrent seizures. Although current therapies exist to control the number and severity of clinical seizures, there are no pharmacological cures or disease-modifying treatments available. Use of transgenic mouse models has allowed an understanding of neural stem cells in their relation to epileptogenesis in mesial temporal lobe epilepsy. Further, with the significant discovery of factors necessary to reprogram adult somatic cell types into pluripotent stem cells, it has become possible to study monogenic epilepsy-in-a-dish using patient-derived neurons. This discovery along with some of the newest technological advances in recapitulating brain development in a dish has brought us closer than ever to a platform in which to study and understand the mechanisms of this disease. These technologies will be critical in understanding the mechanism of epileptogenesis and ultimately lead to improved therapies and precision medicine for patients with epilepsy.",
keywords = "Adult neurogenesis, Epilepsy, Neural stem cells, Organoids, Seizure",
author = "Thodeson, {Drew Michael} and Rebecca Brulet and Jenny Hsieh",
year = "2017",
month = "8",
day = "22",
doi = "10.1007/s00441-017-2675-z",
language = "English (US)",
pages = "1--8",
journal = "Cell and Tissue Research",
issn = "0302-766X",
publisher = "Springer Verlag",

}

TY - JOUR

T1 - Neural stem cells and epilepsy

T2 - functional roles and disease-in-a-dish models

AU - Thodeson, Drew Michael

AU - Brulet, Rebecca

AU - Hsieh, Jenny

PY - 2017/8/22

Y1 - 2017/8/22

N2 - Epilepsy is a disorder of the central nervous system characterized by spontaneous recurrent seizures. Although current therapies exist to control the number and severity of clinical seizures, there are no pharmacological cures or disease-modifying treatments available. Use of transgenic mouse models has allowed an understanding of neural stem cells in their relation to epileptogenesis in mesial temporal lobe epilepsy. Further, with the significant discovery of factors necessary to reprogram adult somatic cell types into pluripotent stem cells, it has become possible to study monogenic epilepsy-in-a-dish using patient-derived neurons. This discovery along with some of the newest technological advances in recapitulating brain development in a dish has brought us closer than ever to a platform in which to study and understand the mechanisms of this disease. These technologies will be critical in understanding the mechanism of epileptogenesis and ultimately lead to improved therapies and precision medicine for patients with epilepsy.

AB - Epilepsy is a disorder of the central nervous system characterized by spontaneous recurrent seizures. Although current therapies exist to control the number and severity of clinical seizures, there are no pharmacological cures or disease-modifying treatments available. Use of transgenic mouse models has allowed an understanding of neural stem cells in their relation to epileptogenesis in mesial temporal lobe epilepsy. Further, with the significant discovery of factors necessary to reprogram adult somatic cell types into pluripotent stem cells, it has become possible to study monogenic epilepsy-in-a-dish using patient-derived neurons. This discovery along with some of the newest technological advances in recapitulating brain development in a dish has brought us closer than ever to a platform in which to study and understand the mechanisms of this disease. These technologies will be critical in understanding the mechanism of epileptogenesis and ultimately lead to improved therapies and precision medicine for patients with epilepsy.

KW - Adult neurogenesis

KW - Epilepsy

KW - Neural stem cells

KW - Organoids

KW - Seizure

UR - http://www.scopus.com/inward/record.url?scp=85027875910&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027875910&partnerID=8YFLogxK

U2 - 10.1007/s00441-017-2675-z

DO - 10.1007/s00441-017-2675-z

M3 - Article

C2 - 28831605

AN - SCOPUS:85027875910

SP - 1

EP - 8

JO - Cell and Tissue Research

JF - Cell and Tissue Research

SN - 0302-766X

ER -