Neural transplantation in Parkinson’s disease

Elmyra V Encarnacion, Robert A. Hauser

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Parkinson’s disease (PD) is a chronic, degenerative disease characterized by a progressive loss of mesencephalic dopaminergic cells in the substantia nigra pars compacta (SNc) resulting in a loss of dopaminergic innervation to the striatum (caudate and putamen). Parkinsonian signs appear after approximately 50% of nigral cells are lost and striatal dopamine levels are reduced 80% (1). The administration of the dopamine precursor levodopa remains the cornerstone of long-term symptomatic medical management. Patients initially experience satisfactory improvement but as the disease progresses, the clinical response is frequently complicated by motor fluctuations and dyskinesias. Increased disability over time also arises in part due to nondopaminergic-responsive symptoms, including balance and cognitive dysfunction. Better treatments are needed to improve the longterm outcome of patients with PD. One approach is the transplantation of cells that might replace those that have been lost due to the disease process.

Original languageEnglish (US)
Title of host publicationHandbook of Parkinson's Disease, Third Edition
PublisherCRC Press
Pages517-539
Number of pages23
ISBN (Electronic)9780203912164
ISBN (Print)9780824742423
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Medicine(all)

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