Neuroendocrine and behavioral responses to challenge with the indirect serotonin agonist dl-fenfluramine in adults with obsessive-compulsive disorder

P. Anne McBride, Michael D. DeMeo, John A. Sweeney, James Halper, J. John Mann, M. Katherine Shear

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Neuroendocrine and behavioral responses to a single 60-mg oral dose of the indirect serotonin agonist dl-fenfluramine were assessed in unmedicated adults with obsessive-compulsive disorder (OCD) and neuroendocrine results contrasted with those in normal control subjects. Net fenfluramine-induced prolactin release did not differ significantly between OCD patients and normal controls. Prolactin responses in the OCD group were not significantly correlated with baseline Yale-Brown Obsessive Compulsive Scale scores for either obsessions or compulsions, but were positively correlated with the baseline Hamilton Depression Scale score and Hamilton Anxiety Scale score. No clear difference in the severity of patients' obsessions or compulsions was found following challenge with fenfluramine versus placebo. Although the present study does not demonstrate a serotonergic abnormality in OCD, this may be more a reflection of limitations of the test procedures than evidence that central nervous system (CNS) serotonergic function is normal in the disorder.

Original languageEnglish (US)
Pages (from-to)19-34
Number of pages16
JournalBiological Psychiatry
Volume31
Issue number1
DOIs
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Biological Psychiatry

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