Neuroendocrine control of gonadotropin secretion

J. C. Porter, D. D. Nansel, G. A. Gudelsky, M. M. Foreman, N. S. Pilotte, C. R. Parker, G. H. Burrows, G. W. Bates, J. D. Madden

Research output: Contribution to journalArticle

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Abstract

Luteinizing hormone releasing hormone (LHRH), a hypothalamic peptide that is concentrated in granules of neurons, has the capacity to release gonadotropins (Luteinizing hormone (LH) and follicle stimulating hormone) from the pituitary gland. LHRH has been found in hypophysial portal blood of rats, monkeys, and rabbits. Antibodies to LHRH depress plasma LH concentrations in castrated animals and evoke testicular atrophy, but passive immunization against LHRH does not block the LH surge induced by estrogen in monkeys. Estrogens, progestin, prolactin, and dopamine have marked effects on LH secretion, yet an association between these effects and altered hypophysial portal blood concentrations of LHRH is not established. In view of the paucity of evidence demonstrating such a cause and effect relationship, two alternative proposals have become tenable. One, hormones and neurotransmitters may not alter the levels of portal blood LHRH, but rather alter the frequency of pulsatile LHRH secretion. Two, hormones, such as estrogens, progesterone, and prolactin, may alter the responsiveness of the gonadotropin-secreting cells to LHRH by affecting the secretion of dopamine.

Original languageEnglish (US)
Pages (from-to)2896-2901
Number of pages6
JournalFederation Proceedings
Volume39
Issue number11
StatePublished - 1980

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Gonadotropins
Gonadotropin-Releasing Hormone
Luteinizing Hormone
Estrogens
Prolactin
Haplorhini
Dopamine
Hormones
Passive Immunization
Follicle Stimulating Hormone
Pituitary Gland
Progestins
Atrophy
Progesterone
Neurotransmitter Agents
Rabbits
Neurons
Peptides
Antibodies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Porter, J. C., Nansel, D. D., Gudelsky, G. A., Foreman, M. M., Pilotte, N. S., Parker, C. R., ... Madden, J. D. (1980). Neuroendocrine control of gonadotropin secretion. Federation Proceedings, 39(11), 2896-2901.

Neuroendocrine control of gonadotropin secretion. / Porter, J. C.; Nansel, D. D.; Gudelsky, G. A.; Foreman, M. M.; Pilotte, N. S.; Parker, C. R.; Burrows, G. H.; Bates, G. W.; Madden, J. D.

In: Federation Proceedings, Vol. 39, No. 11, 1980, p. 2896-2901.

Research output: Contribution to journalArticle

Porter, JC, Nansel, DD, Gudelsky, GA, Foreman, MM, Pilotte, NS, Parker, CR, Burrows, GH, Bates, GW & Madden, JD 1980, 'Neuroendocrine control of gonadotropin secretion', Federation Proceedings, vol. 39, no. 11, pp. 2896-2901.
Porter JC, Nansel DD, Gudelsky GA, Foreman MM, Pilotte NS, Parker CR et al. Neuroendocrine control of gonadotropin secretion. Federation Proceedings. 1980;39(11):2896-2901.
Porter, J. C. ; Nansel, D. D. ; Gudelsky, G. A. ; Foreman, M. M. ; Pilotte, N. S. ; Parker, C. R. ; Burrows, G. H. ; Bates, G. W. ; Madden, J. D. / Neuroendocrine control of gonadotropin secretion. In: Federation Proceedings. 1980 ; Vol. 39, No. 11. pp. 2896-2901.
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