Neurofibromin is required for barrel formation in the mouse somatosensory cortex

Mark E. Lush, Yun Li, Chang Hyuk Kwon, Jian Chen, Luis F. Parada

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The rodent barrel cortex is a useful system to study the role of genes and neuronal activity in the patterning of the nervous system. Several genes encoding either intracellular signaling molecules or neurotransmitter receptors are required for barrel formation. Neurofibromin is a tumor suppressor protein that has Ras GTPase activity, thus attenuating the MAPK (mitogen-activated protein kinase) and and PI-3 kinase (phosphatidylinositol 3-kinase) pathways, and is mutated in humans with the condition neurofibromatosis type 1 (NF1). Neurofibromin is widely expressed in the developing and adult nervous system, and a common feature of NF1 is deficits in intellectual development. In addition, NF1 is an uncommonly high disorder among individuals with autism. Thus, NF1 may have important roles in normal CNS development and function. To explore roles for neurofibromin in the development of the CNS, we took advantage of a mouse conditional allele. We show that mice that lack neurofibromin in the majority of cortical neurons and astrocytes fail to form cortical barrels in the somatosensory cortex, whereas segregation of thalamic axons within the somatosensory cortex appears unaffected.

Original languageEnglish (US)
Pages (from-to)1580-1587
Number of pages8
JournalJournal of Neuroscience
Volume28
Issue number7
DOIs
StatePublished - Feb 13 2008

Fingerprint

Neurofibromin 1
Neurofibromatosis 1
Somatosensory Cortex
Nervous System
MAP Kinase Kinase 3
Phosphatidylinositol 3-Kinase
Tumor Suppressor Proteins
ras Proteins
Neurotransmitter Receptor
Autistic Disorder
Phosphatidylinositol 3-Kinases
Astrocytes
Genes
Axons
Rodentia
Alleles
Neurons

Keywords

  • Conditional mutant
  • Development
  • hGFAP-Cre
  • NF1
  • Ras-GAP
  • Thalamocortical axons

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Neurofibromin is required for barrel formation in the mouse somatosensory cortex. / Lush, Mark E.; Li, Yun; Kwon, Chang Hyuk; Chen, Jian; Parada, Luis F.

In: Journal of Neuroscience, Vol. 28, No. 7, 13.02.2008, p. 1580-1587.

Research output: Contribution to journalArticle

Lush, Mark E. ; Li, Yun ; Kwon, Chang Hyuk ; Chen, Jian ; Parada, Luis F. / Neurofibromin is required for barrel formation in the mouse somatosensory cortex. In: Journal of Neuroscience. 2008 ; Vol. 28, No. 7. pp. 1580-1587.
@article{ee0f0e104d224b84a2024cac57a1b67a,
title = "Neurofibromin is required for barrel formation in the mouse somatosensory cortex",
abstract = "The rodent barrel cortex is a useful system to study the role of genes and neuronal activity in the patterning of the nervous system. Several genes encoding either intracellular signaling molecules or neurotransmitter receptors are required for barrel formation. Neurofibromin is a tumor suppressor protein that has Ras GTPase activity, thus attenuating the MAPK (mitogen-activated protein kinase) and and PI-3 kinase (phosphatidylinositol 3-kinase) pathways, and is mutated in humans with the condition neurofibromatosis type 1 (NF1). Neurofibromin is widely expressed in the developing and adult nervous system, and a common feature of NF1 is deficits in intellectual development. In addition, NF1 is an uncommonly high disorder among individuals with autism. Thus, NF1 may have important roles in normal CNS development and function. To explore roles for neurofibromin in the development of the CNS, we took advantage of a mouse conditional allele. We show that mice that lack neurofibromin in the majority of cortical neurons and astrocytes fail to form cortical barrels in the somatosensory cortex, whereas segregation of thalamic axons within the somatosensory cortex appears unaffected.",
keywords = "Conditional mutant, Development, hGFAP-Cre, NF1, Ras-GAP, Thalamocortical axons",
author = "Lush, {Mark E.} and Yun Li and Kwon, {Chang Hyuk} and Jian Chen and Parada, {Luis F.}",
year = "2008",
month = "2",
day = "13",
doi = "10.1523/JNEUROSCI.5236-07.2008",
language = "English (US)",
volume = "28",
pages = "1580--1587",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "7",

}

TY - JOUR

T1 - Neurofibromin is required for barrel formation in the mouse somatosensory cortex

AU - Lush, Mark E.

AU - Li, Yun

AU - Kwon, Chang Hyuk

AU - Chen, Jian

AU - Parada, Luis F.

PY - 2008/2/13

Y1 - 2008/2/13

N2 - The rodent barrel cortex is a useful system to study the role of genes and neuronal activity in the patterning of the nervous system. Several genes encoding either intracellular signaling molecules or neurotransmitter receptors are required for barrel formation. Neurofibromin is a tumor suppressor protein that has Ras GTPase activity, thus attenuating the MAPK (mitogen-activated protein kinase) and and PI-3 kinase (phosphatidylinositol 3-kinase) pathways, and is mutated in humans with the condition neurofibromatosis type 1 (NF1). Neurofibromin is widely expressed in the developing and adult nervous system, and a common feature of NF1 is deficits in intellectual development. In addition, NF1 is an uncommonly high disorder among individuals with autism. Thus, NF1 may have important roles in normal CNS development and function. To explore roles for neurofibromin in the development of the CNS, we took advantage of a mouse conditional allele. We show that mice that lack neurofibromin in the majority of cortical neurons and astrocytes fail to form cortical barrels in the somatosensory cortex, whereas segregation of thalamic axons within the somatosensory cortex appears unaffected.

AB - The rodent barrel cortex is a useful system to study the role of genes and neuronal activity in the patterning of the nervous system. Several genes encoding either intracellular signaling molecules or neurotransmitter receptors are required for barrel formation. Neurofibromin is a tumor suppressor protein that has Ras GTPase activity, thus attenuating the MAPK (mitogen-activated protein kinase) and and PI-3 kinase (phosphatidylinositol 3-kinase) pathways, and is mutated in humans with the condition neurofibromatosis type 1 (NF1). Neurofibromin is widely expressed in the developing and adult nervous system, and a common feature of NF1 is deficits in intellectual development. In addition, NF1 is an uncommonly high disorder among individuals with autism. Thus, NF1 may have important roles in normal CNS development and function. To explore roles for neurofibromin in the development of the CNS, we took advantage of a mouse conditional allele. We show that mice that lack neurofibromin in the majority of cortical neurons and astrocytes fail to form cortical barrels in the somatosensory cortex, whereas segregation of thalamic axons within the somatosensory cortex appears unaffected.

KW - Conditional mutant

KW - Development

KW - hGFAP-Cre

KW - NF1

KW - Ras-GAP

KW - Thalamocortical axons

UR - http://www.scopus.com/inward/record.url?scp=39549117358&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=39549117358&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.5236-07.2008

DO - 10.1523/JNEUROSCI.5236-07.2008

M3 - Article

VL - 28

SP - 1580

EP - 1587

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 7

ER -