Neuroimmune interactions in a model of multiple sclerosis

C. Jane Welsh, Andrew J. Steelman, Wentao Mi, Colin R. Young, Ralph Storts, Thomas H. Welsh, Mary W. Meagher

Research output: Chapter in Book/Report/Conference proceedingConference contribution

18 Citations (Scopus)

Abstract

Psychological stress has been implicated in both the onset and exacerbation of multiple sclerosis (MS). Our research has focused on the role of stress at the onset of MS, using the mouse model Theiler's murine encephalomyelitis virus-induced demyelination. Theiler's virus is a natural pathogen of mice that causes a persistent infection of the central nervous system (CNS) and inflammatory immune-mediated demyelination that is very similar to MS. Our research has shown that restraint stress sufficiently increases corticosterone secretion to cause immunosuppression. Stressed mice develop decreased innate and adaptive immune responses, including decreased chemokine and cytokine responses, to virus, which leads to increased viral replication within the CNS. Higher levels of virus then cause increased later demyelinating disease. These findings may have important implications in our understanding of the interactions between stress and the development of autoimmune diseases induced by infectious agents.

Original languageEnglish (US)
Title of host publicationAnnals of the New York Academy of Sciences
Pages209-219
Number of pages11
Volume1153
DOIs
StatePublished - Feb 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1153
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Demyelinating Diseases
Viruses
Theilovirus
Multiple Sclerosis
Neurology
Central Nervous System Infections
Adaptive Immunity
Corticosterone
Psychological Stress
Chemokines
Research
Innate Immunity
Immunosuppression
Autoimmune Diseases
Pathogens
Central Nervous System
Cytokines

Keywords

  • Adaptive immunity
  • Autoimmunity
  • CD4 T cells
  • CD8 T cells
  • Central nervous system
  • Chemokines
  • Corticosterone
  • Cytokines
  • Demyelination
  • Glucocorticoids
  • HPA axis
  • Immune system
  • inflammation
  • Innate immunity
  • Interferon
  • Macrophages
  • Multiple sclerosis
  • NK cells
  • Restraint stress
  • Stress
  • T cells
  • Th1
  • Th2
  • Theiler's virus
  • Viruses

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Welsh, C. J., Steelman, A. J., Mi, W., Young, C. R., Storts, R., Welsh, T. H., & Meagher, M. W. (2009). Neuroimmune interactions in a model of multiple sclerosis. In Annals of the New York Academy of Sciences (Vol. 1153, pp. 209-219). (Annals of the New York Academy of Sciences; Vol. 1153). https://doi.org/10.1111/j.1749-6632.2008.03984.x

Neuroimmune interactions in a model of multiple sclerosis. / Welsh, C. Jane; Steelman, Andrew J.; Mi, Wentao; Young, Colin R.; Storts, Ralph; Welsh, Thomas H.; Meagher, Mary W.

Annals of the New York Academy of Sciences. Vol. 1153 2009. p. 209-219 (Annals of the New York Academy of Sciences; Vol. 1153).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Welsh, CJ, Steelman, AJ, Mi, W, Young, CR, Storts, R, Welsh, TH & Meagher, MW 2009, Neuroimmune interactions in a model of multiple sclerosis. in Annals of the New York Academy of Sciences. vol. 1153, Annals of the New York Academy of Sciences, vol. 1153, pp. 209-219. https://doi.org/10.1111/j.1749-6632.2008.03984.x
Welsh CJ, Steelman AJ, Mi W, Young CR, Storts R, Welsh TH et al. Neuroimmune interactions in a model of multiple sclerosis. In Annals of the New York Academy of Sciences. Vol. 1153. 2009. p. 209-219. (Annals of the New York Academy of Sciences). https://doi.org/10.1111/j.1749-6632.2008.03984.x
Welsh, C. Jane ; Steelman, Andrew J. ; Mi, Wentao ; Young, Colin R. ; Storts, Ralph ; Welsh, Thomas H. ; Meagher, Mary W. / Neuroimmune interactions in a model of multiple sclerosis. Annals of the New York Academy of Sciences. Vol. 1153 2009. pp. 209-219 (Annals of the New York Academy of Sciences).
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