Neuropathologic findings in essential tremor

E. D. Louis, J. P.G. Vonsattel, L. S. Honig, G. W. Ross, K. E. Lyons, R. Pahwa

Research output: Contribution to journalArticlepeer-review

116 Scopus citations

Abstract

Pathologic findings, including cerebellar changes and brainstem Lewy bodies, distinguished 10 essential tremor (ET) cases from 12 controls. Numbers of torpedoes (p = 0.009) and Bergmann glia (p = 0.046) were increased in cases. Six cases (60%) had Lewy bodies vs 2 controls (16.7%) (odds ratio 7.5, 95% CI 1.04 to 54.1; p = 0.035). Four of these six had an atypical distribution of brainstem Lewy bodies. ET may be pathologically heterogeneous.

Original languageEnglish (US)
Pages (from-to)1756-1759
Number of pages4
JournalNeurology
Volume66
Issue number11
DOIs
StatePublished - Jun 2006
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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