Neurotrophic factors, their receptors, and the signal transduction pathways they activate

G. D. Yancopoulos, P. C. Maisonpierre, N. Y. Ip, T. H. Aldrich, L. Belluscio, T. G. Boulton, M. H. Cobb, S. P. Squinto, M. E. Furth

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Our studies of the spatiotemporal availability of neurotrophic factors, coupled with tagged ligand binding assays that identify cells bearing receptors for these factors, should lead toward defining the physiological roles of these molecules in the animal. The use of the tagged ligands to identify factor-responsive cell lines has also provided new model systems for the examination of ligand-receptor interactions, as well as for the study of the subsequent induction of intracellular response pathways. To obtain insights into such intracellular pathways, we have molecularly cloned genes encoding a family of serine-threonine protein kinases, most closely related to kinases involved in the yeast response to pheromones. These kinases may be crucial regulators of early steps in the response of mammalian cells to neurotrophic factors as well as other extracellular signals.

Original languageEnglish (US)
Pages (from-to)371-379
Number of pages9
JournalCold Spring Harbor Symposia on Quantitative Biology
Volume55
StatePublished - 1990

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Nerve Growth Factor Receptors
Signal transduction
neurotrophins
signal transduction
Signal Transduction
Nerve Growth Factors
Ligands
receptors
phosphotransferases (kinases)
Bearings (structural)
Phosphotransferases
Cells
Gene encoding
Protein-Serine-Threonine Kinases
Pheromones
Yeast
pheromones
Assays
Animals
Yeasts

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Molecular Biology

Cite this

Yancopoulos, G. D., Maisonpierre, P. C., Ip, N. Y., Aldrich, T. H., Belluscio, L., Boulton, T. G., ... Furth, M. E. (1990). Neurotrophic factors, their receptors, and the signal transduction pathways they activate. Cold Spring Harbor Symposia on Quantitative Biology, 55, 371-379.

Neurotrophic factors, their receptors, and the signal transduction pathways they activate. / Yancopoulos, G. D.; Maisonpierre, P. C.; Ip, N. Y.; Aldrich, T. H.; Belluscio, L.; Boulton, T. G.; Cobb, M. H.; Squinto, S. P.; Furth, M. E.

In: Cold Spring Harbor Symposia on Quantitative Biology, Vol. 55, 1990, p. 371-379.

Research output: Contribution to journalArticle

Yancopoulos, GD, Maisonpierre, PC, Ip, NY, Aldrich, TH, Belluscio, L, Boulton, TG, Cobb, MH, Squinto, SP & Furth, ME 1990, 'Neurotrophic factors, their receptors, and the signal transduction pathways they activate', Cold Spring Harbor Symposia on Quantitative Biology, vol. 55, pp. 371-379.
Yancopoulos GD, Maisonpierre PC, Ip NY, Aldrich TH, Belluscio L, Boulton TG et al. Neurotrophic factors, their receptors, and the signal transduction pathways they activate. Cold Spring Harbor Symposia on Quantitative Biology. 1990;55:371-379.
Yancopoulos, G. D. ; Maisonpierre, P. C. ; Ip, N. Y. ; Aldrich, T. H. ; Belluscio, L. ; Boulton, T. G. ; Cobb, M. H. ; Squinto, S. P. ; Furth, M. E. / Neurotrophic factors, their receptors, and the signal transduction pathways they activate. In: Cold Spring Harbor Symposia on Quantitative Biology. 1990 ; Vol. 55. pp. 371-379.
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