Neutropenic enterocolitis as a presenting complication of acute lymphoblastic leukemia

An unusual case marked by delayed perforation of the descending colon

David B. Wilson, Aarati Rao, Monica Hulbert, Kerry P. Mychaliska, Lori Luchtman-Jones, D. Ashley Hill, Robert P. Foglia

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Neutropenic enterocolitis (NE) is a life-threatening complication most commonly seen in patients receiving intensive chemotherapy for acute leukemia. The condition usually affects the terminal ileum, cecum, or ascending colon. In rare instances, NE may occur before the initiation of chemotherapy or involve more distal bowel. The authors report the case of a 2-year-old girl who had NE affecting the descending colon as a presenting complication of acute lymphoblastic leukemia. Despite aggressive medical interventions, including granulocyte infusions, she had a delayed bowel perforation that was managed successfully with surgery. This case highlights the challenges of treating patients who have NE as an initial manifestation of acute leukemia.

Original languageEnglish (US)
JournalJournal of Pediatric Surgery
Volume39
Issue number7
DOIs
StatePublished - Jul 2004

Fingerprint

Neutropenic Enterocolitis
Descending Colon
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Ascending Colon
Drug Therapy
Cecum
Ileum
Granulocytes

Keywords

  • Acute lymphoblastic leukemia
  • bowel perforation
  • enterocolitis
  • neutropenia
  • typhlitis

ASJC Scopus subject areas

  • Surgery

Cite this

Neutropenic enterocolitis as a presenting complication of acute lymphoblastic leukemia : An unusual case marked by delayed perforation of the descending colon. / Wilson, David B.; Rao, Aarati; Hulbert, Monica; Mychaliska, Kerry P.; Luchtman-Jones, Lori; Hill, D. Ashley; Foglia, Robert P.

In: Journal of Pediatric Surgery, Vol. 39, No. 7, 07.2004.

Research output: Contribution to journalArticle

Wilson, David B. ; Rao, Aarati ; Hulbert, Monica ; Mychaliska, Kerry P. ; Luchtman-Jones, Lori ; Hill, D. Ashley ; Foglia, Robert P. / Neutropenic enterocolitis as a presenting complication of acute lymphoblastic leukemia : An unusual case marked by delayed perforation of the descending colon. In: Journal of Pediatric Surgery. 2004 ; Vol. 39, No. 7.
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