New Developments in CKD-MBD. Why is phosphate overload harmful?

Makoto Kuroo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Phosphate restriction has been shown to improve clinical outcomes in patients with chronic kidney disease (CKD) . However, the molecular mechanism underlying the harm in phosphate overload remains unclear. Recent studies suggest that the true culprit of phosphate toxicity may not be phosphate per se but calciprotein particles (CPPs) , colloidal nanoparticles composed of calcium phosphate crystals and mineral binding proteins such as Fetuin-A. CPPs are highly bioactive ligands that induce cell damage and innate immune responses. Serum levels of CPPs are increased in CKD patients and independently associated with vascular calcification and chronic inflammation. CPPs may be viewed as a "pathogen" that plays an important role in the pathophysiology of CKD.

Original languageEnglish (US)
Pages (from-to)1785-1792
Number of pages8
JournalClinical calcium
Volume24
Issue number12
StatePublished - Dec 1 2014

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Chronic Renal Insufficiency
Phosphates
alpha-2-HS-Glycoprotein
Vascular Calcification
Innate Immunity
Nanoparticles
Minerals
Carrier Proteins
Ligands
Inflammation
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

New Developments in CKD-MBD. Why is phosphate overload harmful? / Kuroo, Makoto.

In: Clinical calcium, Vol. 24, No. 12, 01.12.2014, p. 1785-1792.

Research output: Contribution to journalArticle

Kuroo, Makoto. / New Developments in CKD-MBD. Why is phosphate overload harmful?. In: Clinical calcium. 2014 ; Vol. 24, No. 12. pp. 1785-1792.
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