New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

Bryan A. Gibson, W. Lee Kraus

Research output: Contribution to journalReview article

616 Scopus citations

Abstract

Poly(ADP-ribose) polymerases (PARPs) are enzymes that transfer ADP-ribose groups to target proteins and thereby affect various nuclear and cytoplasmic processes. The activity of PARP family members, such as PARP1 and PARP2, is tied to cellular signalling pathways, and through poly(ADP-ribosyl)ation (PARylation) they ultimately promote changes in gene expression, RNA and protein abundance, and the location and activity of proteins that mediate signalling responses. PARPs act in a complex response network that is driven by the cellular, molecular and chemical biology of poly(ADP-ribose) (PAR). This PAR-dependent response network is crucial for a broad array of physiological and pathological responses and thus is a good target for chemical therapeutics for several diseases.

Original languageEnglish (US)
Pages (from-to)411-424
Number of pages14
JournalNature Reviews Molecular Cell Biology
Volume13
Issue number7
DOIs
StatePublished - Jul 1 2012

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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