New views of cells in 3D: An introduction to electron tomography

Richard McIntosh, Daniela Nicastro, David Mastronarde

Research output: Contribution to journalReview article

307 Scopus citations

Abstract

The most important goal of structural cell biology is to elucidate the mechanisms of the processes of life. The structure of a membrane system or fibrous array, the changes in such structures over time or the localizations of enzymes relative to organelle boundaries can often illuminate associated cellular functions. To be of maximal value, structural studies should provide isotropic, 3D information about well-preserved samples at the highest possible resolution. Electron tomography can provide such information about many kinds of cells and organelles.

Original languageEnglish (US)
Pages (from-to)43-51
Number of pages9
JournalTrends in Cell Biology
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2005

ASJC Scopus subject areas

  • Cell Biology

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