No Association of Vitamin D pathway genetic variants with cancer risks in a population-based cohort of German older adults

José Manuel Ordóñez-Mena, Ben Schottker, Kai U. Saum, Bernd Holleczek, Barbara Burwinkel, Thomas J. Wang, Hermann Brenner

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background: Several investigations assessed the association of Vitamin D receptor (VDR) SNPs with cancer risk. Less is known about the implications of other Vitamin D pathway SNPs on cancer risk. Methods: In a population-based cohort study of 9,949 German older adults, we used Cox regression to assess the association of 6 SNPs in the VDR, Vitamin D-binding protein (GC), 7-dehydrocholesterol reductase (DHCR7), Vitamin D 25- hydroxylase (CYP2R1), and Vitamin D 24-hydroxylase (CYP24A1) genes with total and site-specific cancer incidence endpoints. Results: Overall, no association of SNPs with cancer incidence endpoints was observed, except for a genotype score based on SNPs associated with lower 25(OH)D, which was associated with higher lung cancer risk [HR, 1.20; 95% confidence intervals (CI), 1.03-1.39], although this was no longer significant after correcting for multiple testing. Conclusions: Our data provide little to no evidence of a major influence of Vitamin D genetic predisposition on cancer risks. Impact: Large-scale genetic epidemiology consortia and metaanalysis of smaller published studies are needed to verify a potential modest influence of genetic variation in the association of Vitamin D with the risk of cancer.

Original languageEnglish (US)
Pages (from-to)1459-1461
Number of pages3
JournalCancer Epidemiology Biomarkers and Prevention
Volume26
Issue number9
DOIs
StatePublished - Sep 1 2017
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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