TY - JOUR
T1 - No Association of Vitamin D pathway genetic variants with cancer risks in a population-based cohort of German older adults
AU - Ordóñez-Mena, José Manuel
AU - Schottker, Ben
AU - Saum, Kai U.
AU - Holleczek, Bernd
AU - Burwinkel, Barbara
AU - Wang, Thomas J.
AU - Brenner, Hermann
N1 - Funding Information:
The ESTHER study was funded by the Baden-Wu€rttemberg state Ministry of Science, Research and Arts (Stuttgart, Germany), the Federal Ministry of Education and Research (Berlin, Germany), and the Federal Ministry of Family Affairs, Senior Citizens, Women and Youth (Berlin, Germany). The work of JoséM. Ordóñez-Mena was supported by a scholarship from the Klaus Tschira Foundation (Klaus Tschira Stiftung gemeinnu€tzige GmbH) within the framework of a PhD program in the Network Aging Research (Netzwerk Alternsforschung).
Publisher Copyright:
© 2017 American Association for Cancer Research.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Background: Several investigations assessed the association of Vitamin D receptor (VDR) SNPs with cancer risk. Less is known about the implications of other Vitamin D pathway SNPs on cancer risk. Methods: In a population-based cohort study of 9,949 German older adults, we used Cox regression to assess the association of 6 SNPs in the VDR, Vitamin D-binding protein (GC), 7-dehydrocholesterol reductase (DHCR7), Vitamin D 25- hydroxylase (CYP2R1), and Vitamin D 24-hydroxylase (CYP24A1) genes with total and site-specific cancer incidence endpoints. Results: Overall, no association of SNPs with cancer incidence endpoints was observed, except for a genotype score based on SNPs associated with lower 25(OH)D, which was associated with higher lung cancer risk [HR, 1.20; 95% confidence intervals (CI), 1.03-1.39], although this was no longer significant after correcting for multiple testing. Conclusions: Our data provide little to no evidence of a major influence of Vitamin D genetic predisposition on cancer risks. Impact: Large-scale genetic epidemiology consortia and metaanalysis of smaller published studies are needed to verify a potential modest influence of genetic variation in the association of Vitamin D with the risk of cancer.
AB - Background: Several investigations assessed the association of Vitamin D receptor (VDR) SNPs with cancer risk. Less is known about the implications of other Vitamin D pathway SNPs on cancer risk. Methods: In a population-based cohort study of 9,949 German older adults, we used Cox regression to assess the association of 6 SNPs in the VDR, Vitamin D-binding protein (GC), 7-dehydrocholesterol reductase (DHCR7), Vitamin D 25- hydroxylase (CYP2R1), and Vitamin D 24-hydroxylase (CYP24A1) genes with total and site-specific cancer incidence endpoints. Results: Overall, no association of SNPs with cancer incidence endpoints was observed, except for a genotype score based on SNPs associated with lower 25(OH)D, which was associated with higher lung cancer risk [HR, 1.20; 95% confidence intervals (CI), 1.03-1.39], although this was no longer significant after correcting for multiple testing. Conclusions: Our data provide little to no evidence of a major influence of Vitamin D genetic predisposition on cancer risks. Impact: Large-scale genetic epidemiology consortia and metaanalysis of smaller published studies are needed to verify a potential modest influence of genetic variation in the association of Vitamin D with the risk of cancer.
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U2 - 10.1158/1055-9965.EPI-17-0191
DO - 10.1158/1055-9965.EPI-17-0191
M3 - Article
C2 - 28864453
AN - SCOPUS:85028916823
VL - 26
SP - 1459
EP - 1461
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
SN - 1055-9965
IS - 9
ER -