Nocturnal eczema: Review of sleep and circadian rhythms in children with atopic dermatitis and future research directions

Anna B. Fishbein; Olivia Vitaterna; Isabel M. Haugh; Aakash A. Bavishi; Phyllis C. Zee; Fred W. Turek; Stephen H. Sheldon; Jonathan I. Silverberg; Amy S. Paller

doi:10.1016/j.jaci.2015.08.028

Nocturnal eczema: Review of sleep and circadian rhythms in children with atopic dermatitis and future research directions

Anna B. Fishbein, Olivia Vitaterna, Isabel M. Haugh, Aakash A. Bavishi, Phyllis C. Zee, Fred W. Turek, Stephen H. Sheldon, Jonathan I. Silverberg, Amy S. Paller

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

Children with atopic dermatitis (AD) experience significant sleep disruption, and clinically, the disease is noted to worsen in a circadian manner at night. Epidemiologic findings highlight many negative consequences of AD, such as impaired linear growth, which is uniquely related to disturbed sleep. Clinical guidelines currently recommend assessing sleep in patients with AD as a crucial parameter of disease control with appropriate treatment. In this review we describe our current understanding of the roles of sleep cycles and circadian rhythms in the nighttime exacerbation of AD (nocturnal eczema). We present a schematic to explain the mechanism of nocturnal eczema. Treatment options for sleep disturbance and future directions for research are discussed in the context of AD.

Original language	English (US)
Pages (from-to)	1170-1177
Number of pages	8
Journal	Journal of Allergy and Clinical Immunology
Volume	136
Issue number	5
DOIs	https://doi.org/10.1016/j.jaci.2015.08.028
State	Published - Nov 1 2015
Externally published	Yes

Keywords

Atopic dermatitis
circadian rhythms
eczema
sleep
sleep disturbance

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.jaci.2015.08.028

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Fishbein, A. B., Vitaterna, O., Haugh, I. M., Bavishi, A. A., Zee, P. C., Turek, F. W., Sheldon, S. H., Silverberg, J. I., & Paller, A. S. (2015). Nocturnal eczema: Review of sleep and circadian rhythms in children with atopic dermatitis and future research directions. Journal of Allergy and Clinical Immunology, 136(5), 1170-1177. https://doi.org/10.1016/j.jaci.2015.08.028

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title = "Nocturnal eczema: Review of sleep and circadian rhythms in children with atopic dermatitis and future research directions",

abstract = "Children with atopic dermatitis (AD) experience significant sleep disruption, and clinically, the disease is noted to worsen in a circadian manner at night. Epidemiologic findings highlight many negative consequences of AD, such as impaired linear growth, which is uniquely related to disturbed sleep. Clinical guidelines currently recommend assessing sleep in patients with AD as a crucial parameter of disease control with appropriate treatment. In this review we describe our current understanding of the roles of sleep cycles and circadian rhythms in the nighttime exacerbation of AD (nocturnal eczema). We present a schematic to explain the mechanism of nocturnal eczema. Treatment options for sleep disturbance and future directions for research are discussed in the context of AD.",

keywords = "Atopic dermatitis, circadian rhythms, eczema, sleep, sleep disturbance",

author = "Fishbein, {Anna B.} and Olivia Vitaterna and Haugh, {Isabel M.} and Bavishi, {Aakash A.} and Zee, {Phyllis C.} and Turek, {Fred W.} and Sheldon, {Stephen H.} and Silverberg, {Jonathan I.} and Paller, {Amy S.}",

note = "Publisher Copyright: {\textcopyright} 2015 American Academy of Allergy, Asthma & Immunology.",

year = "2015",

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doi = "10.1016/j.jaci.2015.08.028",

language = "English (US)",

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pages = "1170--1177",

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TY - JOUR

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T2 - Review of sleep and circadian rhythms in children with atopic dermatitis and future research directions

AU - Fishbein, Anna B.

AU - Vitaterna, Olivia

AU - Haugh, Isabel M.

AU - Bavishi, Aakash A.

AU - Zee, Phyllis C.

AU - Turek, Fred W.

AU - Sheldon, Stephen H.

AU - Silverberg, Jonathan I.

AU - Paller, Amy S.

PY - 2015/11/1

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N2 - Children with atopic dermatitis (AD) experience significant sleep disruption, and clinically, the disease is noted to worsen in a circadian manner at night. Epidemiologic findings highlight many negative consequences of AD, such as impaired linear growth, which is uniquely related to disturbed sleep. Clinical guidelines currently recommend assessing sleep in patients with AD as a crucial parameter of disease control with appropriate treatment. In this review we describe our current understanding of the roles of sleep cycles and circadian rhythms in the nighttime exacerbation of AD (nocturnal eczema). We present a schematic to explain the mechanism of nocturnal eczema. Treatment options for sleep disturbance and future directions for research are discussed in the context of AD.

AB - Children with atopic dermatitis (AD) experience significant sleep disruption, and clinically, the disease is noted to worsen in a circadian manner at night. Epidemiologic findings highlight many negative consequences of AD, such as impaired linear growth, which is uniquely related to disturbed sleep. Clinical guidelines currently recommend assessing sleep in patients with AD as a crucial parameter of disease control with appropriate treatment. In this review we describe our current understanding of the roles of sleep cycles and circadian rhythms in the nighttime exacerbation of AD (nocturnal eczema). We present a schematic to explain the mechanism of nocturnal eczema. Treatment options for sleep disturbance and future directions for research are discussed in the context of AD.

KW - Atopic dermatitis

KW - circadian rhythms

KW - eczema

KW - sleep

KW - sleep disturbance

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ER -

Nocturnal eczema: Review of sleep and circadian rhythms in children with atopic dermatitis and future research directions

Abstract

Keywords

ASJC Scopus subject areas

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