Nodular regenerative hyperplasia of the liver in a case of myelofibrosis with extramedullary hematopoiesis and secondary portal venous hypertension

J. Shorey, M. N. Weinberg, E. P. Frenkel, B. D. Fallis

Research output: Contribution to journalArticle

21 Scopus citations


Nodular regenerative hyperplasia of the liver was identified at autopsy in a patient with myelofibrosis with extramedullary hematopoiesis, an association not previously reported. Portal venous hypertension, documented during the patient's terminal hospitalization, was ascribed, in part, to a high rate of blood flow through the enlarged spleen. Possible mechanisms accounting for the development of nodular regenerative hyperplasia of the liver, and evidence provided by this case pertinent to these mechanisms, are discussed.

Original languageEnglish (US)
Pages (from-to)122-125
Number of pages4
JournalAmerican Journal of Clinical Pathology
Issue number1
Publication statusPublished - 1979


ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this