Nodular regenerative hyperplasia of the liver was identified at autopsy in a patient with myelofibrosis with extramedullary hematopoiesis, an association not previously reported. Portal venous hypertension, documented during the patient's terminal hospitalization, was ascribed, in part, to a high rate of blood flow through the enlarged spleen. Possible mechanisms accounting for the development of nodular regenerative hyperplasia of the liver, and evidence provided by this case pertinent to these mechanisms, are discussed.
ASJC Scopus subject areas
- Pathology and Forensic Medicine