Nomograms including nuclear matrix protein 22 for prediction of disease recurrence and progression in patients with Ta, T1 or CIS transitional cell carcinoma of the bladder

Shahrokh F. Shariat, Craig Zippe, Gerson Lübecke, Hans Boman, Marta Sanchez-Carbayo, Roberto Casella, Christine Mian, Martin G. Friedrich, Sanaa Eissa, Hideyuki Akaza, Ihor Sawczuk, Vincenzo Serretta, Hartwig Huland, Hans Hedelin, Raina Rupesh, Naoto Miyanaga, Arthur I Sagalowsky, Frank Wians, Claus Roehrborn, Yair LotanPaul Perrotte, Serge Benayoun, Michael J. Marberger, Pierre I. Karakiewicz

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Purpose: We developed and validated nomograms that accurately predict disease recurrence and progression in patients with Ta, T1, or CIS transitional cell carcinoma (TCC) of the bladder using a large international cohort. Methods: Univariate and multivariate logistic regression models targeted histologically confirmed disease recurrence, and focused on 2,542 patients with bladder TCC from 10 participating centers. Variables consisted of pre-cystoscopy voided urine Nuclear Matrix Protein 22 (NMP22) assay, urine cytology, age and gender. Resulting nomograms were internally validated with bootstrapping. Nomogram performance was explored graphically with Loess smoothing plots. Results: Overall 957 patients had recurrent TCC. Tumor grade and stage was available for 898 patients, including 24% grade I, 43% grade II, and 33% grade III; 45% stage Ta, 32% T1 and/or CIS, and 23% T2 or greater. Bootstrap corrected predictive accuracy for any TCC recurrence was 0.842; grade III Ta/T1 or CIS was 0.869; and T2 or higher stage TCC of any grade was 0.858, Virtually perfect performance characteristics were observed for the nomograms predicting any TCC recurrence or grade III Ta/T1 or CIS. The nomogram predicting T2 or higher stage TCC overestimated the observed probability for predicted values greater than 45%. Conclusions: We developed and internally validated nomograms that incorporate urinary NMP22, cytology, age and gender to predict with high accuracy the probability of disease recurrence and progression in patients with Ta, T1, and/or CIS bladder TCC. These nomograms could provide a means for individualizing followup in patients with Ta, T1, CIS bladder TCC.

Original languageEnglish (US)
Pages (from-to)1518-1525
Number of pages8
JournalJournal of Urology
Volume173
Issue number5
DOIs
StatePublished - May 2005

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Nomograms
Transitional Cell Carcinoma
Disease Progression
Urinary Bladder
Recurrence
Cell Biology
Logistic Models
Urine
nuclear matrix protein 22
Cystoscopy

Keywords

  • Bladder neoplasms
  • Neoplasm staging
  • Nomograms
  • Nuclear matrix protein 22

ASJC Scopus subject areas

  • Urology

Cite this

Nomograms including nuclear matrix protein 22 for prediction of disease recurrence and progression in patients with Ta, T1 or CIS transitional cell carcinoma of the bladder. / Shariat, Shahrokh F.; Zippe, Craig; Lübecke, Gerson; Boman, Hans; Sanchez-Carbayo, Marta; Casella, Roberto; Mian, Christine; Friedrich, Martin G.; Eissa, Sanaa; Akaza, Hideyuki; Sawczuk, Ihor; Serretta, Vincenzo; Huland, Hartwig; Hedelin, Hans; Rupesh, Raina; Miyanaga, Naoto; Sagalowsky, Arthur I; Wians, Frank; Roehrborn, Claus; Lotan, Yair; Perrotte, Paul; Benayoun, Serge; Marberger, Michael J.; Karakiewicz, Pierre I.

In: Journal of Urology, Vol. 173, No. 5, 05.2005, p. 1518-1525.

Research output: Contribution to journalArticle

Shariat, SF, Zippe, C, Lübecke, G, Boman, H, Sanchez-Carbayo, M, Casella, R, Mian, C, Friedrich, MG, Eissa, S, Akaza, H, Sawczuk, I, Serretta, V, Huland, H, Hedelin, H, Rupesh, R, Miyanaga, N, Sagalowsky, AI, Wians, F, Roehrborn, C, Lotan, Y, Perrotte, P, Benayoun, S, Marberger, MJ & Karakiewicz, PI 2005, 'Nomograms including nuclear matrix protein 22 for prediction of disease recurrence and progression in patients with Ta, T1 or CIS transitional cell carcinoma of the bladder', Journal of Urology, vol. 173, no. 5, pp. 1518-1525. https://doi.org/10.1097/01.ju.0000154696.48217.75
Shariat, Shahrokh F. ; Zippe, Craig ; Lübecke, Gerson ; Boman, Hans ; Sanchez-Carbayo, Marta ; Casella, Roberto ; Mian, Christine ; Friedrich, Martin G. ; Eissa, Sanaa ; Akaza, Hideyuki ; Sawczuk, Ihor ; Serretta, Vincenzo ; Huland, Hartwig ; Hedelin, Hans ; Rupesh, Raina ; Miyanaga, Naoto ; Sagalowsky, Arthur I ; Wians, Frank ; Roehrborn, Claus ; Lotan, Yair ; Perrotte, Paul ; Benayoun, Serge ; Marberger, Michael J. ; Karakiewicz, Pierre I. / Nomograms including nuclear matrix protein 22 for prediction of disease recurrence and progression in patients with Ta, T1 or CIS transitional cell carcinoma of the bladder. In: Journal of Urology. 2005 ; Vol. 173, No. 5. pp. 1518-1525.
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abstract = "Purpose: We developed and validated nomograms that accurately predict disease recurrence and progression in patients with Ta, T1, or CIS transitional cell carcinoma (TCC) of the bladder using a large international cohort. Methods: Univariate and multivariate logistic regression models targeted histologically confirmed disease recurrence, and focused on 2,542 patients with bladder TCC from 10 participating centers. Variables consisted of pre-cystoscopy voided urine Nuclear Matrix Protein 22 (NMP22) assay, urine cytology, age and gender. Resulting nomograms were internally validated with bootstrapping. Nomogram performance was explored graphically with Loess smoothing plots. Results: Overall 957 patients had recurrent TCC. Tumor grade and stage was available for 898 patients, including 24{\%} grade I, 43{\%} grade II, and 33{\%} grade III; 45{\%} stage Ta, 32{\%} T1 and/or CIS, and 23{\%} T2 or greater. Bootstrap corrected predictive accuracy for any TCC recurrence was 0.842; grade III Ta/T1 or CIS was 0.869; and T2 or higher stage TCC of any grade was 0.858, Virtually perfect performance characteristics were observed for the nomograms predicting any TCC recurrence or grade III Ta/T1 or CIS. The nomogram predicting T2 or higher stage TCC overestimated the observed probability for predicted values greater than 45{\%}. Conclusions: We developed and internally validated nomograms that incorporate urinary NMP22, cytology, age and gender to predict with high accuracy the probability of disease recurrence and progression in patients with Ta, T1, and/or CIS bladder TCC. These nomograms could provide a means for individualizing followup in patients with Ta, T1, CIS bladder TCC.",
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T1 - Nomograms including nuclear matrix protein 22 for prediction of disease recurrence and progression in patients with Ta, T1 or CIS transitional cell carcinoma of the bladder

AU - Shariat, Shahrokh F.

AU - Zippe, Craig

AU - Lübecke, Gerson

AU - Boman, Hans

AU - Sanchez-Carbayo, Marta

AU - Casella, Roberto

AU - Mian, Christine

AU - Friedrich, Martin G.

AU - Eissa, Sanaa

AU - Akaza, Hideyuki

AU - Sawczuk, Ihor

AU - Serretta, Vincenzo

AU - Huland, Hartwig

AU - Hedelin, Hans

AU - Rupesh, Raina

AU - Miyanaga, Naoto

AU - Sagalowsky, Arthur I

AU - Wians, Frank

AU - Roehrborn, Claus

AU - Lotan, Yair

AU - Perrotte, Paul

AU - Benayoun, Serge

AU - Marberger, Michael J.

AU - Karakiewicz, Pierre I.

PY - 2005/5

Y1 - 2005/5

N2 - Purpose: We developed and validated nomograms that accurately predict disease recurrence and progression in patients with Ta, T1, or CIS transitional cell carcinoma (TCC) of the bladder using a large international cohort. Methods: Univariate and multivariate logistic regression models targeted histologically confirmed disease recurrence, and focused on 2,542 patients with bladder TCC from 10 participating centers. Variables consisted of pre-cystoscopy voided urine Nuclear Matrix Protein 22 (NMP22) assay, urine cytology, age and gender. Resulting nomograms were internally validated with bootstrapping. Nomogram performance was explored graphically with Loess smoothing plots. Results: Overall 957 patients had recurrent TCC. Tumor grade and stage was available for 898 patients, including 24% grade I, 43% grade II, and 33% grade III; 45% stage Ta, 32% T1 and/or CIS, and 23% T2 or greater. Bootstrap corrected predictive accuracy for any TCC recurrence was 0.842; grade III Ta/T1 or CIS was 0.869; and T2 or higher stage TCC of any grade was 0.858, Virtually perfect performance characteristics were observed for the nomograms predicting any TCC recurrence or grade III Ta/T1 or CIS. The nomogram predicting T2 or higher stage TCC overestimated the observed probability for predicted values greater than 45%. Conclusions: We developed and internally validated nomograms that incorporate urinary NMP22, cytology, age and gender to predict with high accuracy the probability of disease recurrence and progression in patients with Ta, T1, and/or CIS bladder TCC. These nomograms could provide a means for individualizing followup in patients with Ta, T1, CIS bladder TCC.

AB - Purpose: We developed and validated nomograms that accurately predict disease recurrence and progression in patients with Ta, T1, or CIS transitional cell carcinoma (TCC) of the bladder using a large international cohort. Methods: Univariate and multivariate logistic regression models targeted histologically confirmed disease recurrence, and focused on 2,542 patients with bladder TCC from 10 participating centers. Variables consisted of pre-cystoscopy voided urine Nuclear Matrix Protein 22 (NMP22) assay, urine cytology, age and gender. Resulting nomograms were internally validated with bootstrapping. Nomogram performance was explored graphically with Loess smoothing plots. Results: Overall 957 patients had recurrent TCC. Tumor grade and stage was available for 898 patients, including 24% grade I, 43% grade II, and 33% grade III; 45% stage Ta, 32% T1 and/or CIS, and 23% T2 or greater. Bootstrap corrected predictive accuracy for any TCC recurrence was 0.842; grade III Ta/T1 or CIS was 0.869; and T2 or higher stage TCC of any grade was 0.858, Virtually perfect performance characteristics were observed for the nomograms predicting any TCC recurrence or grade III Ta/T1 or CIS. The nomogram predicting T2 or higher stage TCC overestimated the observed probability for predicted values greater than 45%. Conclusions: We developed and internally validated nomograms that incorporate urinary NMP22, cytology, age and gender to predict with high accuracy the probability of disease recurrence and progression in patients with Ta, T1, and/or CIS bladder TCC. These nomograms could provide a means for individualizing followup in patients with Ta, T1, CIS bladder TCC.

KW - Bladder neoplasms

KW - Neoplasm staging

KW - Nomograms

KW - Nuclear matrix protein 22

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