Non-contrast quantitative pulmonary perfusion using flow alternating inversion recovery at 3 T: A preliminary study

Joshua S. Greer, Christopher D. Maroules, Orhan K Oz, Suhny Abbara, Ronald M Peshock, Ivan Pedrosa, Ananth J Madhuranthakam

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Abstract

Purpose To demonstrate the initial feasibility of non-contrast quantitative pulmonary perfusion imaging at 3 T using flow alternating inversion recovery (FAIR), and to evaluate the intra-session and inter-session reliability of FAIR measurements at 3 T. Materials and methods Nine healthy volunteers were imaged using our own implementation of FAIR pulse sequence at 3 T. Quantitative FAIR perfusion, both with and without larger pulmonary vessels, was correlated with global phase contrast (PC) measured blood flow in the right pulmonary artery (RPA). The same volunteers were also imaged with SPECT perfusion using technetium-99 m-macroaggregated albumin and relative dispersion (RD) was assessed between FAIR and SPECT perfusion. Four additional healthy volunteers were evaluated for FAIR repeatability, using intra-class correlation coefficient (ICC) and Bland-Altman analysis. p < 0.05 was considered statistically significant. Results FAIR perfusion across all subjects was 858 ± 605 mL/100 g/min (with vessels) and 629 ± 294 mL/100 g/min (without vessels) and correlated significantly with the PC measured blood flow in the RPA (r = 0.62, p < 0.01 with vessels; r = 0.73, p < 0.001 without vessels). The median RD of FAIR perfusion across all subjects was 0.73 (with vessels) and 0.49 (without vessels), compared against 0.23 with SPECT perfusion. The intra/inter-session ICC of FAIR perfusion with vessels was 0.95/0.59 and improved to 0.96/0.72, when vessels were removed. Conclusions Non-contrast quantitative pulmonary perfusion imaging using FAIR is feasible at 3 T. This may serve as a reliable method to assess regional lung perfusion at 3 T to characterize and monitor treatment response in chronic lung disease without the concerns of repeated exposure to ionizing radiation or the accumulation of exogenous contrast agent.

Original languageEnglish (US)
Pages (from-to)106-113
Number of pages8
JournalMagnetic Resonance Imaging
Volume46
DOIs
StatePublished - Feb 1 2018

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Perfusion
Recovery
Lung
Single-Photon Emission-Computed Tomography
Perfusion Imaging
Pulmonary Artery
Healthy Volunteers
Blood
Technetium
Imaging techniques
Ionizing Radiation
Pulmonary diseases
Contrast Media
Lung Diseases
Ionizing radiation
Volunteers
Albumins
Chronic Disease

Keywords

  • 3 T
  • ASL
  • FAIR
  • Lung
  • Perfusion

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

@article{d3ef065115634abbae6c01aa5c5649c2,
title = "Non-contrast quantitative pulmonary perfusion using flow alternating inversion recovery at 3 T: A preliminary study",
abstract = "Purpose To demonstrate the initial feasibility of non-contrast quantitative pulmonary perfusion imaging at 3 T using flow alternating inversion recovery (FAIR), and to evaluate the intra-session and inter-session reliability of FAIR measurements at 3 T. Materials and methods Nine healthy volunteers were imaged using our own implementation of FAIR pulse sequence at 3 T. Quantitative FAIR perfusion, both with and without larger pulmonary vessels, was correlated with global phase contrast (PC) measured blood flow in the right pulmonary artery (RPA). The same volunteers were also imaged with SPECT perfusion using technetium-99 m-macroaggregated albumin and relative dispersion (RD) was assessed between FAIR and SPECT perfusion. Four additional healthy volunteers were evaluated for FAIR repeatability, using intra-class correlation coefficient (ICC) and Bland-Altman analysis. p < 0.05 was considered statistically significant. Results FAIR perfusion across all subjects was 858 ± 605 mL/100 g/min (with vessels) and 629 ± 294 mL/100 g/min (without vessels) and correlated significantly with the PC measured blood flow in the RPA (r = 0.62, p < 0.01 with vessels; r = 0.73, p < 0.001 without vessels). The median RD of FAIR perfusion across all subjects was 0.73 (with vessels) and 0.49 (without vessels), compared against 0.23 with SPECT perfusion. The intra/inter-session ICC of FAIR perfusion with vessels was 0.95/0.59 and improved to 0.96/0.72, when vessels were removed. Conclusions Non-contrast quantitative pulmonary perfusion imaging using FAIR is feasible at 3 T. This may serve as a reliable method to assess regional lung perfusion at 3 T to characterize and monitor treatment response in chronic lung disease without the concerns of repeated exposure to ionizing radiation or the accumulation of exogenous contrast agent.",
keywords = "3 T, ASL, FAIR, Lung, Perfusion",
author = "Greer, {Joshua S.} and Maroules, {Christopher D.} and Oz, {Orhan K} and Suhny Abbara and Peshock, {Ronald M} and Ivan Pedrosa and Madhuranthakam, {Ananth J}",
year = "2018",
month = "2",
day = "1",
doi = "10.1016/j.mri.2017.11.007",
language = "English (US)",
volume = "46",
pages = "106--113",
journal = "Magnetic Resonance Imaging",
issn = "0730-725X",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Non-contrast quantitative pulmonary perfusion using flow alternating inversion recovery at 3 T

T2 - A preliminary study

AU - Greer, Joshua S.

AU - Maroules, Christopher D.

AU - Oz, Orhan K

AU - Abbara, Suhny

AU - Peshock, Ronald M

AU - Pedrosa, Ivan

AU - Madhuranthakam, Ananth J

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Purpose To demonstrate the initial feasibility of non-contrast quantitative pulmonary perfusion imaging at 3 T using flow alternating inversion recovery (FAIR), and to evaluate the intra-session and inter-session reliability of FAIR measurements at 3 T. Materials and methods Nine healthy volunteers were imaged using our own implementation of FAIR pulse sequence at 3 T. Quantitative FAIR perfusion, both with and without larger pulmonary vessels, was correlated with global phase contrast (PC) measured blood flow in the right pulmonary artery (RPA). The same volunteers were also imaged with SPECT perfusion using technetium-99 m-macroaggregated albumin and relative dispersion (RD) was assessed between FAIR and SPECT perfusion. Four additional healthy volunteers were evaluated for FAIR repeatability, using intra-class correlation coefficient (ICC) and Bland-Altman analysis. p < 0.05 was considered statistically significant. Results FAIR perfusion across all subjects was 858 ± 605 mL/100 g/min (with vessels) and 629 ± 294 mL/100 g/min (without vessels) and correlated significantly with the PC measured blood flow in the RPA (r = 0.62, p < 0.01 with vessels; r = 0.73, p < 0.001 without vessels). The median RD of FAIR perfusion across all subjects was 0.73 (with vessels) and 0.49 (without vessels), compared against 0.23 with SPECT perfusion. The intra/inter-session ICC of FAIR perfusion with vessels was 0.95/0.59 and improved to 0.96/0.72, when vessels were removed. Conclusions Non-contrast quantitative pulmonary perfusion imaging using FAIR is feasible at 3 T. This may serve as a reliable method to assess regional lung perfusion at 3 T to characterize and monitor treatment response in chronic lung disease without the concerns of repeated exposure to ionizing radiation or the accumulation of exogenous contrast agent.

AB - Purpose To demonstrate the initial feasibility of non-contrast quantitative pulmonary perfusion imaging at 3 T using flow alternating inversion recovery (FAIR), and to evaluate the intra-session and inter-session reliability of FAIR measurements at 3 T. Materials and methods Nine healthy volunteers were imaged using our own implementation of FAIR pulse sequence at 3 T. Quantitative FAIR perfusion, both with and without larger pulmonary vessels, was correlated with global phase contrast (PC) measured blood flow in the right pulmonary artery (RPA). The same volunteers were also imaged with SPECT perfusion using technetium-99 m-macroaggregated albumin and relative dispersion (RD) was assessed between FAIR and SPECT perfusion. Four additional healthy volunteers were evaluated for FAIR repeatability, using intra-class correlation coefficient (ICC) and Bland-Altman analysis. p < 0.05 was considered statistically significant. Results FAIR perfusion across all subjects was 858 ± 605 mL/100 g/min (with vessels) and 629 ± 294 mL/100 g/min (without vessels) and correlated significantly with the PC measured blood flow in the RPA (r = 0.62, p < 0.01 with vessels; r = 0.73, p < 0.001 without vessels). The median RD of FAIR perfusion across all subjects was 0.73 (with vessels) and 0.49 (without vessels), compared against 0.23 with SPECT perfusion. The intra/inter-session ICC of FAIR perfusion with vessels was 0.95/0.59 and improved to 0.96/0.72, when vessels were removed. Conclusions Non-contrast quantitative pulmonary perfusion imaging using FAIR is feasible at 3 T. This may serve as a reliable method to assess regional lung perfusion at 3 T to characterize and monitor treatment response in chronic lung disease without the concerns of repeated exposure to ionizing radiation or the accumulation of exogenous contrast agent.

KW - 3 T

KW - ASL

KW - FAIR

KW - Lung

KW - Perfusion

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U2 - 10.1016/j.mri.2017.11.007

DO - 10.1016/j.mri.2017.11.007

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VL - 46

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JO - Magnetic Resonance Imaging

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SN - 0730-725X

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