Non-uniform tumor vascular oxygen dynamics monitored by three-channel near-infrared spectroscopy

Jae G. Kim, Yueqing Gu, Anca Constantinescu, Ralph P. Mason, Hanli Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

In a previous report, we showed that there was distinct heterogeneity in tumor oxygenation dynamics even within the same tumor monitored by 19F MR pO 2 mapping and near-infrared spectroscopy (NIRS). In this study, we applied a three-channel NIRS system to reveal dynamic heterogeneity of tumor vascular oxygenation during respiratory challenges. When the implanted tumors reached ∼3 cm, three photo detectors were attached to the surface of the tumor in three different positions to measure changes in oxygenated hemoglobin concentration ([HbO 2]), while the inhaled gas was alternated between air and carbogen (95% O 2 + 5% CO 2). Significant changes in tumor oxygenation were observed at all three detectors accompanying the respiratory challenge, and these changes could be modeled with two exponential components with fast and slow time constants. Time constant, amplitude, vascular coefficient, and the ratio of perfusion rate were obtained from fitting curves of Δ[HbO 2]. These parameters revealed that there were indeed different responses of tumor vascular oxygenation during carbogen inhalation at the three different locations. These results clearly reveal that tumors are highly heterogeneous during vascular oxygenation in response to carbogen inhalation. This study demonstrates that the NIR technology can provide an efficient, real-time, non-invasive way for monitoring tumor physiology, and it may have prognostic value, providing insight into tumor vascular development and angiogenesis.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsB. Chance, R.R. Alfano, B.J. Tromberg, M. Tamura, E.M. Sevick-Muraca
Pages388-396
Number of pages9
Volume4955
DOIs
StatePublished - 2003
EventPROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Optical Tomography and Spectroscopy of Tissue V - San Jose, CA, United States
Duration: Jan 26 2003Jan 29 2003

Other

OtherPROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Optical Tomography and Spectroscopy of Tissue V
CountryUnited States
CitySan Jose, CA
Period1/26/031/29/03

Fingerprint

Near infrared spectroscopy
Tumors
tumors
infrared spectroscopy
Oxygen
Oxygenation
oxygenation
oxygen
respiration
time constant
Detectors
angiogenesis
physiology
Hemoglobin
detectors
Physiology
curve fitting
hemoglobin
Curve fitting

Keywords

  • Carbogen
  • NIR spectroscopy
  • Tumor heterogeneity
  • Tumor vascular oxygenation

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Kim, J. G., Gu, Y., Constantinescu, A., Mason, R. P., & Liu, H. (2003). Non-uniform tumor vascular oxygen dynamics monitored by three-channel near-infrared spectroscopy. In B. Chance, R. R. Alfano, B. J. Tromberg, M. Tamura, & E. M. Sevick-Muraca (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4955, pp. 388-396) https://doi.org/10.1117/12.479800

Non-uniform tumor vascular oxygen dynamics monitored by three-channel near-infrared spectroscopy. / Kim, Jae G.; Gu, Yueqing; Constantinescu, Anca; Mason, Ralph P.; Liu, Hanli.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / B. Chance; R.R. Alfano; B.J. Tromberg; M. Tamura; E.M. Sevick-Muraca. Vol. 4955 2003. p. 388-396.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kim, JG, Gu, Y, Constantinescu, A, Mason, RP & Liu, H 2003, Non-uniform tumor vascular oxygen dynamics monitored by three-channel near-infrared spectroscopy. in B Chance, RR Alfano, BJ Tromberg, M Tamura & EM Sevick-Muraca (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4955, pp. 388-396, PROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Optical Tomography and Spectroscopy of Tissue V, San Jose, CA, United States, 1/26/03. https://doi.org/10.1117/12.479800
Kim JG, Gu Y, Constantinescu A, Mason RP, Liu H. Non-uniform tumor vascular oxygen dynamics monitored by three-channel near-infrared spectroscopy. In Chance B, Alfano RR, Tromberg BJ, Tamura M, Sevick-Muraca EM, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4955. 2003. p. 388-396 https://doi.org/10.1117/12.479800
Kim, Jae G. ; Gu, Yueqing ; Constantinescu, Anca ; Mason, Ralph P. ; Liu, Hanli. / Non-uniform tumor vascular oxygen dynamics monitored by three-channel near-infrared spectroscopy. Proceedings of SPIE - The International Society for Optical Engineering. editor / B. Chance ; R.R. Alfano ; B.J. Tromberg ; M. Tamura ; E.M. Sevick-Muraca. Vol. 4955 2003. pp. 388-396
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