TY - JOUR
T1 - Noniatrogenic neonatal gastric perforation
T2 - The role of interstitial cells of cajal
AU - Jactel, Samuel Noah
AU - Abramowsky, Carlos R.
AU - Schniederjan, Matthew
AU - Durham, Megan M.
AU - Ricketts, Richard R.
AU - Clifton, Matthew S.
AU - Langberg, Karl M.
AU - Elawabdeh, Nancy
AU - Pandya, Samir
AU - Talebagha, Sarah
AU - Shehata, Bahig M.
PY - 2013/12
Y1 - 2013/12
N2 - Noniatrogenic neonatal gastric perforation is a rare and life-threatening condition whose etiology is often unclear. Interstitial cells of Cajal act as gastrointestinal pacemaker cells and express the proto-oncogene c-Kit. Six new cases were identified at our institution which presented with no mechanical, pharmacologic, or otherwise medical-related intervention prior to rupture. The number of interstitial cells of Cajal in nonnecrotic muscularis propria from five random high-power fields per specimen was compared using immunohistochemical stains for c-Kit. The authors show that a lack of interstitial cells of Cajal in the stomach musculature may be implicated in the development of noniatrogenic gastric perforation (p = 0.008). Further large-scale studies, including molecular and genetic analysis, may help to better understand this phenomenon.
AB - Noniatrogenic neonatal gastric perforation is a rare and life-threatening condition whose etiology is often unclear. Interstitial cells of Cajal act as gastrointestinal pacemaker cells and express the proto-oncogene c-Kit. Six new cases were identified at our institution which presented with no mechanical, pharmacologic, or otherwise medical-related intervention prior to rupture. The number of interstitial cells of Cajal in nonnecrotic muscularis propria from five random high-power fields per specimen was compared using immunohistochemical stains for c-Kit. The authors show that a lack of interstitial cells of Cajal in the stomach musculature may be implicated in the development of noniatrogenic gastric perforation (p = 0.008). Further large-scale studies, including molecular and genetic analysis, may help to better understand this phenomenon.
KW - C-Kit
KW - CD117
KW - Interstitial cells of Cajal (ICC)
KW - Neonatal gastric perforation (NGP)
UR - http://www.scopus.com/inward/record.url?scp=84887932398&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84887932398&partnerID=8YFLogxK
U2 - 10.3109/15513815.2013.799248
DO - 10.3109/15513815.2013.799248
M3 - Article
C2 - 23742621
AN - SCOPUS:84887932398
SN - 1551-3815
VL - 32
SP - 422
EP - 428
JO - Fetal and Pediatric Pathology
JF - Fetal and Pediatric Pathology
IS - 6
ER -