Nonmotor symptoms of Parkinson’s disease

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

Parkinson’s disease is generally thought of first and foremost as a disorder of motor control. The cardinal signs of PD are all motor defects, which generally respond favorably to dopaminergic stimulation. While the most obvious pathological change in PD is degeneration of pigmented neurons in the substantia nigra, many other neuronal pathways not involved in motor function (such as the noradrenergic locus ceruleus, the serotonergic raphe nuclei, and the cholinergic nucleus basalis of Meynert) also degenerate in this disease (1). It is not surprising, therefore, that nonmotor symptoms abound in this patient population (Table 1). In this chapter we will consider the most common and important nonmotor symptoms seen in PD and, where possible, discuss therapeutic options for these problems.

Original languageEnglish (US)
Title of host publicationHandbook of Parkinson's Disease, Third Edition
PublisherCRC Press
Pages109-126
Number of pages18
ISBN (Electronic)9780203912164
ISBN (Print)9780824742423
StatePublished - Jan 1 2003

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Basal Nucleus of Meynert
Nerve Degeneration
Raphe Nuclei
Locus Coeruleus
Substantia Nigra
Cholinergic Agents
Parkinson Disease
Population
Therapeutics
Motor Disorders

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dewey, R. B. (2003). Nonmotor symptoms of Parkinson’s disease. In Handbook of Parkinson's Disease, Third Edition (pp. 109-126). CRC Press.

Nonmotor symptoms of Parkinson’s disease. / Dewey, Richard B.

Handbook of Parkinson's Disease, Third Edition. CRC Press, 2003. p. 109-126.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dewey, RB 2003, Nonmotor symptoms of Parkinson’s disease. in Handbook of Parkinson's Disease, Third Edition. CRC Press, pp. 109-126.
Dewey RB. Nonmotor symptoms of Parkinson’s disease. In Handbook of Parkinson's Disease, Third Edition. CRC Press. 2003. p. 109-126
Dewey, Richard B. / Nonmotor symptoms of Parkinson’s disease. Handbook of Parkinson's Disease, Third Edition. CRC Press, 2003. pp. 109-126
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