Not so EEZE: The 'EDHF' antagonist 14, 15 epoxyeicosa-5(Z)-enoic acid has vasodilator properties in mesenteric arteries

Louise S. Harrington, J R Falck, Jane A. Mitchell

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

P-450 metabolites, including the epoxyeicosatrienoic acids, are likely candidates for endothelial derived hyperpolarising factor (EDHF). In the present study, we confirm that the stable analogue 11-nonyloxyundec-8(Z)-enoic acid is a vasodilator of murine vessels. However, we also show that the 'epoxyeicosatrienoic acid receptor' antagonist 14,15 EEZE similarly dilates murine vessels contracted with U46619, prostaglandin F or methoxamine, but not with endothelin-1 or potassium. We suggest that 14,15 EEZE is a partial agonist for the epoxyeicosatrienoic acids/EDHF receptor. These results illustrate an important pharmacological property of this antagonists, which is being increasingly used to study the nature of EDHF.

Original languageEnglish (US)
Pages (from-to)165-168
Number of pages4
JournalEuropean Journal of Pharmacology
Volume506
Issue number2
DOIs
StatePublished - Dec 15 2004

Keywords

  • 14,15 EEZE
  • EDHF (Endothelial derived hyperpolarising factor)
  • Hyperpolarisation
  • Mesenteric artery
  • U46619
  • mouse

ASJC Scopus subject areas

  • Pharmacology

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