Notch signaling as a therapeutic target

Yunsun Nam, Jon C. Aster, Stephen C. Blacklow

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Signals transduced by Notch receptors influence differentiation and proliferation in a wide variety of cell types. Activation of a Notch signal by one of several ligands triggers a series of proteolytic cleavages that release the intracellular region of Notch from the membrane, allowing it ultimately to translocate to the nucleus and activate the transcription of downstream target genes. Recent studies have elucidated the roles of several key proteins that participate in and modulate these central events in Notch signal transduction. These advances offer a variety of potential avenues to manipulate Notch signaling for therapeutic purposes in the treatment of cancer and in stem cell maintenance.

Original languageEnglish (US)
Pages (from-to)501-509
Number of pages9
JournalCurrent Opinion in Chemical Biology
Volume6
Issue number4
DOIs
StatePublished - Aug 1 2002

Fingerprint

Notch Receptors
Signal transduction
Neoplastic Stem Cells
Transcription
Stem cells
Signal Transduction
Genes
Chemical activation
Maintenance
Ligands
Membranes
Proteins
Therapeutics

ASJC Scopus subject areas

  • Biochemistry

Cite this

Notch signaling as a therapeutic target. / Nam, Yunsun; Aster, Jon C.; Blacklow, Stephen C.

In: Current Opinion in Chemical Biology, Vol. 6, No. 4, 01.08.2002, p. 501-509.

Research output: Contribution to journalArticle

Nam, Yunsun ; Aster, Jon C. ; Blacklow, Stephen C. / Notch signaling as a therapeutic target. In: Current Opinion in Chemical Biology. 2002 ; Vol. 6, No. 4. pp. 501-509.
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