Novel synthetic ligands for targeted PET imaging and radiotherapy of copper

Hyun Soon Chong, Santosh Mhaske, Mai Lin, Sankar Bhuniya, Hyun A. Song, Martin W. Brechbiel, Xiankai Sun

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Novel ligands, NBEA, NBPA, NETA, NE3TA, and NE3TA-Bn, were synthesized and evaluated as potential chelators of copper radioisotopes for use in targeted positron emission tomography (PET) imaging or radiation therapy. The new ligands were radiolabeled with 64Cu, and in vitro stability of the radiolabeled complexes was assessed in rat serum. Serum stability results suggest that among the ligands tested, NETA, NE3TA, and NE3TA-Bn form stable complexes with 64Cu.

Original languageEnglish (US)
Pages (from-to)6107-6110
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number22
DOIs
StatePublished - Nov 15 2007

Keywords

  • Cu-64
  • Macrocyclic ligands
  • PET imaging
  • Serum stability
  • Synthetic chelates
  • Targeted radiotherapy

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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