Nuclear receptors, coactivators and chromatin: New approaches, new insights

Kathleen C. Lee, W. Lee Kraus

Research output: Contribution to journalReview article

59 Scopus citations

Abstract

The actions of lipophilic hormones, including steroids, retinoids, thyroid hormone and vitamin D3, are mediated through a conserved superfamily of nuclear receptor proteins that function as ligand-regulated, DNA-binding transcriptional activators in the chromatin environment of the nucleus. The ligand-dependent transcriptional activity of nuclear receptors is enhanced by various cofactors that remodel chromatin, acetylate nucleosomal histones and contact the basal transcriptional machinery. The current challenge is to understand the mechanistic details of how interactions among these factors enhance transcription of hormone-regulated genes assembled into chromatin. Current biochemical and cell-based methods are providing some important clues.

Original languageEnglish (US)
Pages (from-to)191-197
Number of pages7
JournalTrends in Endocrinology and Metabolism
Volume12
Issue number5
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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