Old dogs, new trick: classic cancer therapies activate cGAS

Seoyun Yum, Minghao Li, Zhijian J. Chen

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

The discovery of cancer immune surveillance and immunotherapy has opened up a new era of cancer treatment. Immunotherapies modulate a patient’s immune system to specifically eliminate cancer cells; thus, it is considered a very different approach from classic cancer therapies that usually induce DNA damage to cause cell death in a cell-intrinsic manner. However, recent studies have revealed that classic cancer therapies such as radiotherapy and chemotherapy also elicit antitumor immunity, which plays an essential role in their therapeutic efficacy. The cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) and the downstream effector Stimulator of Interferon Genes (STING) have been determined to be critical for this interplay. Here, we review the antitumor roles of the cGAS-STING pathway during tumorigenesis, cancer immune surveillance, and cancer therapies. We also highlight classic cancer therapies that elicit antitumor immune responses through cGAS activation.

Original languageEnglish (US)
Pages (from-to)639-648
Number of pages10
JournalCell Research
Volume30
Issue number8
DOIs
StatePublished - Aug 1 2020

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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