TY - JOUR
T1 - Olfactory ensheathing cells
T2 - Biology in neural development and regeneration
AU - Su, Zhida
AU - He, Cheng
N1 - Funding Information:
This work was supported by the National Natural Science Foundation ( 30700209 , 30770657 ), National Key Basic Research Program ( 2006CB500702 , 2007CB947100 , 2011CB504401 ), and the Ministry of Science and Technology of China ( 2009ZX09311-001 ).
PY - 2010/12
Y1 - 2010/12
N2 - Olfactory ensheathing cells (OECs) constitute a unique population of glia that accompany and ensheath the primary olfactory axons. They are thought to be critical for spontaneous growth of olfactory axons within the developing and adult olfactory nervous system, and have recently emerged as potential candidates for cell-mediated repair of neural injuries. Here, based on the current research, we give an overview of the biology of OECs in neural development and regeneration. This review starts with a detailed description of the cellular and molecular biological properties of OECs. Their functions in olfactory neurogenesis, olfactory axonal growth and olfactory bulb formation are sequently discussed. We also describe therapeutic applications of OECs for the treatment of a variety of neural lesions, including spinal cord injury, stroke, degenerative diseases, and PNS injuries. Finally, we address issues that may foster a better understanding of OECs in neural development and regeneration.
AB - Olfactory ensheathing cells (OECs) constitute a unique population of glia that accompany and ensheath the primary olfactory axons. They are thought to be critical for spontaneous growth of olfactory axons within the developing and adult olfactory nervous system, and have recently emerged as potential candidates for cell-mediated repair of neural injuries. Here, based on the current research, we give an overview of the biology of OECs in neural development and regeneration. This review starts with a detailed description of the cellular and molecular biological properties of OECs. Their functions in olfactory neurogenesis, olfactory axonal growth and olfactory bulb formation are sequently discussed. We also describe therapeutic applications of OECs for the treatment of a variety of neural lesions, including spinal cord injury, stroke, degenerative diseases, and PNS injuries. Finally, we address issues that may foster a better understanding of OECs in neural development and regeneration.
KW - Glial cells
KW - Neural injury
KW - Olfactory development
KW - Olfactory ensheathing cells
KW - Regeneration
UR - http://www.scopus.com/inward/record.url?scp=77957736762&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957736762&partnerID=8YFLogxK
U2 - 10.1016/j.pneurobio.2010.08.008
DO - 10.1016/j.pneurobio.2010.08.008
M3 - Review article
C2 - 20837090
AN - SCOPUS:77957736762
SN - 0301-0082
VL - 92
SP - 517
EP - 532
JO - Progress in Neurobiology
JF - Progress in Neurobiology
IS - 4
ER -