One-pot arylative epoxidation of ketones by employing amphoteric bromoperfluoroarenes

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8 Scopus citations

Abstract

A one-pot cascade synthesis of perfluoroaryl oxiranes 2 by the arylative epoxidation of enolizable ketones 1 with bromopentafluorobenzene (PFPBr) and derivatives (3) is reported. PFPBr is utilized as an equivalent of Br + and PFP - in this highly efficient, easily scaled-up, diastereoselective epoxidation reaction, which produces synthetically useful polyfluoroaryl oxiranes.

Original languageEnglish (US)
Pages (from-to)1225-1227
Number of pages3
JournalAngewandte Chemie - International Edition
Volume51
Issue number5
DOIs
StatePublished - Jan 27 2012

Keywords

  • bromopentafluorobenzene
  • cascade transformations
  • epoxidation
  • perfluorinated compounds
  • perfluoroarylepoxides

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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