Ontogeny of human fetal plasma progesterone, deoxycorticosterone, and deoxycorticosterone sulfate

C. R. Parker, B. R. Carr, S. R. Ragland, J. C. Morrison, W. N P Herbert, P. C. MacDonald

Research output: Contribution to journalArticle

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Abstract

The concentrations of progesterone, deoxycorticosterone (DOC), and deoxycorticosterone sulfate (DOC-SO4) were determined in mixed umbilical cord plasma of abortuses and newborn infants delivered between 18 and 42 weeks' gestation. A wide range of values among individual samples was found for progesterone (224 to 2,152 ng/ml), DOC (1.6 to 10.4 ng/ml), and DOC-SO4 (17 to 154 ng/ml). Levels of progesterone and DOC in mixed umbilical cord plasma were not correlated; those of DOC and DOC-SO4 were positively correlated significantly (r = 0.3945, P < 0.001). Whereas the mean plasma levels of DOC were similar throughout gestation, significant variation, as a function of gestational age, was found for progesterone and DOC-SO4, with levels of these steroids generally being higher near term than earlier in gestation. The administration of glucocorticosteroids to the mother resulted in a significant decrease (p < 0.001) in plasma concentrations of DOC and DOC-SO4 in the newborn infant; levels of progesterone in umbilical cord plasma were not affected by maternal glucocorticosteroid treatment. These results suggest that the fetal adrenal glands play a direct, or possibly an indirect, role in the production of the DOC and DOC-SO4 that is present in the fetal compartment. In addition, since fetal plasma levels of progesterone are quite high throughout gestation, the potential exists for circulating progesterone to serve as a precursor for adrenal and extra-adrenal production of DOC and DOC-SO4.

Original languageEnglish (US)
Pages (from-to)955-959
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume147
Issue number8
StatePublished - Dec 15 1983

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Desoxycorticosterone
Progesterone
Umbilical Cord
Pregnancy
deoxycorticosterone sulfate
Mothers
Newborn Infant
Adrenal Glands

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Parker, C. R., Carr, B. R., Ragland, S. R., Morrison, J. C., Herbert, W. N. P., & MacDonald, P. C. (1983). Ontogeny of human fetal plasma progesterone, deoxycorticosterone, and deoxycorticosterone sulfate. American Journal of Obstetrics and Gynecology, 147(8), 955-959.

Ontogeny of human fetal plasma progesterone, deoxycorticosterone, and deoxycorticosterone sulfate. / Parker, C. R.; Carr, B. R.; Ragland, S. R.; Morrison, J. C.; Herbert, W. N P; MacDonald, P. C.

In: American Journal of Obstetrics and Gynecology, Vol. 147, No. 8, 15.12.1983, p. 955-959.

Research output: Contribution to journalArticle

Parker, CR, Carr, BR, Ragland, SR, Morrison, JC, Herbert, WNP & MacDonald, PC 1983, 'Ontogeny of human fetal plasma progesterone, deoxycorticosterone, and deoxycorticosterone sulfate', American Journal of Obstetrics and Gynecology, vol. 147, no. 8, pp. 955-959.
Parker, C. R. ; Carr, B. R. ; Ragland, S. R. ; Morrison, J. C. ; Herbert, W. N P ; MacDonald, P. C. / Ontogeny of human fetal plasma progesterone, deoxycorticosterone, and deoxycorticosterone sulfate. In: American Journal of Obstetrics and Gynecology. 1983 ; Vol. 147, No. 8. pp. 955-959.
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