Opening a Chromatin Gate to Metastasis

John D. Minna; Jane E. Johnson

doi:10.1016/j.cell.2016.06.031

Opening a Chromatin Gate to Metastasis

John D. Minna, Jane E. Johnson

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

What changes need to occur in a primary tumor to make it metastatic? Denny et al. address this question for small cell lung cancer (SCLC), finding that changes in genomic accessibility mediated by a single transcription factor, NFIB, comprise at least one mechanism influencing metastasis.

Original language	English (US)
Pages (from-to)	275-276
Number of pages	2
Journal	Cell
Volume	166
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2016.06.031
State	Published - 2016

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2016.06.031

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title = "Opening a Chromatin Gate to Metastasis",

abstract = "What changes need to occur in a primary tumor to make it metastatic? Denny et al. address this question for small cell lung cancer (SCLC), finding that changes in genomic accessibility mediated by a single transcription factor, NFIB, comprise at least one mechanism influencing metastasis.",

author = "Minna, {John D.} and Johnson, {Jane E.}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2016",

doi = "10.1016/j.cell.2016.06.031",

language = "English (US)",

volume = "166",

pages = "275--276",

journal = "Cell",

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T1 - Opening a Chromatin Gate to Metastasis

AU - Minna, John D.

AU - Johnson, Jane E.

PY - 2016

Y1 - 2016

N2 - What changes need to occur in a primary tumor to make it metastatic? Denny et al. address this question for small cell lung cancer (SCLC), finding that changes in genomic accessibility mediated by a single transcription factor, NFIB, comprise at least one mechanism influencing metastasis.

AB - What changes need to occur in a primary tumor to make it metastatic? Denny et al. address this question for small cell lung cancer (SCLC), finding that changes in genomic accessibility mediated by a single transcription factor, NFIB, comprise at least one mechanism influencing metastasis.

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U2 - 10.1016/j.cell.2016.06.031

DO - 10.1016/j.cell.2016.06.031

M3 - Short survey

C2 - 27419866

AN - SCOPUS:84982162351

SN - 0092-8674

VL - 166

SP - 275

EP - 276

JO - Cell

JF - Cell

IS - 2

ER -

Opening a Chromatin Gate to Metastasis

Abstract

ASJC Scopus subject areas

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