Abstract

What changes need to occur in a primary tumor to make it metastatic? Denny et al. address this question for small cell lung cancer (SCLC), finding that changes in genomic accessibility mediated by a single transcription factor, NFIB, comprise at least one mechanism influencing metastasis.

Original languageEnglish (US)
Pages (from-to)275-276
Number of pages2
JournalCell
Volume166
Issue number2
DOIs
StatePublished - 2016

Fingerprint

Small Cell Lung Carcinoma
Chromatin
Tumors
Transcription Factors
Cells
Neoplasm Metastasis
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Opening a Chromatin Gate to Metastasis. / Minna, John D.; Johnson, Jane E.

In: Cell, Vol. 166, No. 2, 2016, p. 275-276.

Research output: Contribution to journalShort survey

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