Optical coherence tomography analysis of the stenting of saphenous vein graft (SOS) xience v study: Use of the everolimus-eluting stent in saphenous vein graft lesions

Aristotelis C. Papayannis, Tesfaldet T. Michael, Dinara Yangirova, Abdul Rahman Abdel-Karim, Julia Kohlhaas, Arif Mahmood, Tayo Addo, Donald Haagen, Lorenza Makke, Michele Roesle, Bavana Rangan, Subhash Banerjee, Emmanouil S. Brilakis

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objectives: The Stenting of Saphenous Grafts-Xience V (SOS-Xience V) trial prospectively examined the frequency of angiographic in-stent restenosis in saphenous vein graft (SVG) lesions 12 months after implantation of a Xience V everolimus-eluting stent (EES; Abbott Vascular). Optical coherence tomography (OCT) during follow-up angiography was added to the protocol after OCT was approved for clinical use in the United States. Methods: Forty patients with 40 SVG lesions were enrolled in the study, of whom 27 underwent 12-month coronary angiography and 12 (only 1 of whom had in-stent restenosis) also had follow-up OCT evaluation. OCT strut-level analysis was performed to determine the percentage of strut coverage, malapposition, strut protrusion, neointimal thickness, and the existence of thrombus. Results: Mean patient age was 67 ± 7 years, and 95% were men. A total of 2584 struts were evaluated by OCT. The percentages for uncovered, malapposed, and protruding struts were 4%, 9%, and 15%, respectively. The mean strut neointimal thickness was 0.094 ± 0.094 mm. Of the 12 stents analyzed, 4 (33%) showed full neointimal coverage, 2 (17%) had all the struts embedded, 7 (58%) had at least 1 malapposed strut, and 10 (83%) had at least 1 protruding strut. The mean difference between the stent area and the lumen area was 0.36 ± 1.6 mm. No thrombus was detected in the stented areas. CONCLUSIONS: Use of EES in SVGs is associated with high rates of stent strut coverage and high malapposition rates at 12 months post implantation.

Original languageEnglish (US)
Pages (from-to)390-394
Number of pages5
JournalJournal of Invasive Cardiology
Volume24
Issue number8
StatePublished - Aug 2012

Fingerprint

Saphenous Vein
Optical Coherence Tomography
Stents
Transplants
Thrombosis
Coronary Angiography
Blood Vessels
Everolimus
Angiography

Keywords

  • coronary artery bypass graft surgery
  • drug-eluting stents
  • optical coherence tomography
  • percutaneous coronary intervention
  • saphenous vein grafts

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Optical coherence tomography analysis of the stenting of saphenous vein graft (SOS) xience v study : Use of the everolimus-eluting stent in saphenous vein graft lesions. / Papayannis, Aristotelis C.; Michael, Tesfaldet T.; Yangirova, Dinara; Abdel-Karim, Abdul Rahman; Kohlhaas, Julia; Mahmood, Arif; Addo, Tayo; Haagen, Donald; Makke, Lorenza; Roesle, Michele; Rangan, Bavana; Banerjee, Subhash; Brilakis, Emmanouil S.

In: Journal of Invasive Cardiology, Vol. 24, No. 8, 08.2012, p. 390-394.

Research output: Contribution to journalArticle

Papayannis, AC, Michael, TT, Yangirova, D, Abdel-Karim, AR, Kohlhaas, J, Mahmood, A, Addo, T, Haagen, D, Makke, L, Roesle, M, Rangan, B, Banerjee, S & Brilakis, ES 2012, 'Optical coherence tomography analysis of the stenting of saphenous vein graft (SOS) xience v study: Use of the everolimus-eluting stent in saphenous vein graft lesions', Journal of Invasive Cardiology, vol. 24, no. 8, pp. 390-394.
Papayannis, Aristotelis C. ; Michael, Tesfaldet T. ; Yangirova, Dinara ; Abdel-Karim, Abdul Rahman ; Kohlhaas, Julia ; Mahmood, Arif ; Addo, Tayo ; Haagen, Donald ; Makke, Lorenza ; Roesle, Michele ; Rangan, Bavana ; Banerjee, Subhash ; Brilakis, Emmanouil S. / Optical coherence tomography analysis of the stenting of saphenous vein graft (SOS) xience v study : Use of the everolimus-eluting stent in saphenous vein graft lesions. In: Journal of Invasive Cardiology. 2012 ; Vol. 24, No. 8. pp. 390-394.
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abstract = "Objectives: The Stenting of Saphenous Grafts-Xience V (SOS-Xience V) trial prospectively examined the frequency of angiographic in-stent restenosis in saphenous vein graft (SVG) lesions 12 months after implantation of a Xience V everolimus-eluting stent (EES; Abbott Vascular). Optical coherence tomography (OCT) during follow-up angiography was added to the protocol after OCT was approved for clinical use in the United States. Methods: Forty patients with 40 SVG lesions were enrolled in the study, of whom 27 underwent 12-month coronary angiography and 12 (only 1 of whom had in-stent restenosis) also had follow-up OCT evaluation. OCT strut-level analysis was performed to determine the percentage of strut coverage, malapposition, strut protrusion, neointimal thickness, and the existence of thrombus. Results: Mean patient age was 67 ± 7 years, and 95{\%} were men. A total of 2584 struts were evaluated by OCT. The percentages for uncovered, malapposed, and protruding struts were 4{\%}, 9{\%}, and 15{\%}, respectively. The mean strut neointimal thickness was 0.094 ± 0.094 mm. Of the 12 stents analyzed, 4 (33{\%}) showed full neointimal coverage, 2 (17{\%}) had all the struts embedded, 7 (58{\%}) had at least 1 malapposed strut, and 10 (83{\%}) had at least 1 protruding strut. The mean difference between the stent area and the lumen area was 0.36 ± 1.6 mm. No thrombus was detected in the stented areas. CONCLUSIONS: Use of EES in SVGs is associated with high rates of stent strut coverage and high malapposition rates at 12 months post implantation.",
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author = "Papayannis, {Aristotelis C.} and Michael, {Tesfaldet T.} and Dinara Yangirova and Abdel-Karim, {Abdul Rahman} and Julia Kohlhaas and Arif Mahmood and Tayo Addo and Donald Haagen and Lorenza Makke and Michele Roesle and Bavana Rangan and Subhash Banerjee and Brilakis, {Emmanouil S.}",
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T1 - Optical coherence tomography analysis of the stenting of saphenous vein graft (SOS) xience v study

T2 - Use of the everolimus-eluting stent in saphenous vein graft lesions

AU - Papayannis, Aristotelis C.

AU - Michael, Tesfaldet T.

AU - Yangirova, Dinara

AU - Abdel-Karim, Abdul Rahman

AU - Kohlhaas, Julia

AU - Mahmood, Arif

AU - Addo, Tayo

AU - Haagen, Donald

AU - Makke, Lorenza

AU - Roesle, Michele

AU - Rangan, Bavana

AU - Banerjee, Subhash

AU - Brilakis, Emmanouil S.

PY - 2012/8

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N2 - Objectives: The Stenting of Saphenous Grafts-Xience V (SOS-Xience V) trial prospectively examined the frequency of angiographic in-stent restenosis in saphenous vein graft (SVG) lesions 12 months after implantation of a Xience V everolimus-eluting stent (EES; Abbott Vascular). Optical coherence tomography (OCT) during follow-up angiography was added to the protocol after OCT was approved for clinical use in the United States. Methods: Forty patients with 40 SVG lesions were enrolled in the study, of whom 27 underwent 12-month coronary angiography and 12 (only 1 of whom had in-stent restenosis) also had follow-up OCT evaluation. OCT strut-level analysis was performed to determine the percentage of strut coverage, malapposition, strut protrusion, neointimal thickness, and the existence of thrombus. Results: Mean patient age was 67 ± 7 years, and 95% were men. A total of 2584 struts were evaluated by OCT. The percentages for uncovered, malapposed, and protruding struts were 4%, 9%, and 15%, respectively. The mean strut neointimal thickness was 0.094 ± 0.094 mm. Of the 12 stents analyzed, 4 (33%) showed full neointimal coverage, 2 (17%) had all the struts embedded, 7 (58%) had at least 1 malapposed strut, and 10 (83%) had at least 1 protruding strut. The mean difference between the stent area and the lumen area was 0.36 ± 1.6 mm. No thrombus was detected in the stented areas. CONCLUSIONS: Use of EES in SVGs is associated with high rates of stent strut coverage and high malapposition rates at 12 months post implantation.

AB - Objectives: The Stenting of Saphenous Grafts-Xience V (SOS-Xience V) trial prospectively examined the frequency of angiographic in-stent restenosis in saphenous vein graft (SVG) lesions 12 months after implantation of a Xience V everolimus-eluting stent (EES; Abbott Vascular). Optical coherence tomography (OCT) during follow-up angiography was added to the protocol after OCT was approved for clinical use in the United States. Methods: Forty patients with 40 SVG lesions were enrolled in the study, of whom 27 underwent 12-month coronary angiography and 12 (only 1 of whom had in-stent restenosis) also had follow-up OCT evaluation. OCT strut-level analysis was performed to determine the percentage of strut coverage, malapposition, strut protrusion, neointimal thickness, and the existence of thrombus. Results: Mean patient age was 67 ± 7 years, and 95% were men. A total of 2584 struts were evaluated by OCT. The percentages for uncovered, malapposed, and protruding struts were 4%, 9%, and 15%, respectively. The mean strut neointimal thickness was 0.094 ± 0.094 mm. Of the 12 stents analyzed, 4 (33%) showed full neointimal coverage, 2 (17%) had all the struts embedded, 7 (58%) had at least 1 malapposed strut, and 10 (83%) had at least 1 protruding strut. The mean difference between the stent area and the lumen area was 0.36 ± 1.6 mm. No thrombus was detected in the stented areas. CONCLUSIONS: Use of EES in SVGs is associated with high rates of stent strut coverage and high malapposition rates at 12 months post implantation.

KW - coronary artery bypass graft surgery

KW - drug-eluting stents

KW - optical coherence tomography

KW - percutaneous coronary intervention

KW - saphenous vein grafts

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