Optical coherence tomography analysis of the stenting of saphenous vein graft (SOS) xience v study: Use of the everolimus-eluting stent in saphenous vein graft lesions

Aristotelis C. Papayannis, Tesfaldet T. Michael, Dinara Yangirova, Abdul Rahman Abdel-Karim, Julia Kohlhaas, Arif Mahmood, Tayo Addo, Donald Haagen, Lorenza Makke, Michele Roesle, Bavana Rangan, Subhash Banerjee, Emmanouil S. Brilakis

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Objectives: The Stenting of Saphenous Grafts-Xience V (SOS-Xience V) trial prospectively examined the frequency of angiographic in-stent restenosis in saphenous vein graft (SVG) lesions 12 months after implantation of a Xience V everolimus-eluting stent (EES; Abbott Vascular). Optical coherence tomography (OCT) during follow-up angiography was added to the protocol after OCT was approved for clinical use in the United States. Methods: Forty patients with 40 SVG lesions were enrolled in the study, of whom 27 underwent 12-month coronary angiography and 12 (only 1 of whom had in-stent restenosis) also had follow-up OCT evaluation. OCT strut-level analysis was performed to determine the percentage of strut coverage, malapposition, strut protrusion, neointimal thickness, and the existence of thrombus. Results: Mean patient age was 67 ± 7 years, and 95% were men. A total of 2584 struts were evaluated by OCT. The percentages for uncovered, malapposed, and protruding struts were 4%, 9%, and 15%, respectively. The mean strut neointimal thickness was 0.094 ± 0.094 mm. Of the 12 stents analyzed, 4 (33%) showed full neointimal coverage, 2 (17%) had all the struts embedded, 7 (58%) had at least 1 malapposed strut, and 10 (83%) had at least 1 protruding strut. The mean difference between the stent area and the lumen area was 0.36 ± 1.6 mm. No thrombus was detected in the stented areas. CONCLUSIONS: Use of EES in SVGs is associated with high rates of stent strut coverage and high malapposition rates at 12 months post implantation.

Original languageEnglish (US)
Pages (from-to)390-394
Number of pages5
JournalJournal of Invasive Cardiology
Volume24
Issue number8
StatePublished - Aug 1 2012

Keywords

  • coronary artery bypass graft surgery
  • drug-eluting stents
  • optical coherence tomography
  • percutaneous coronary intervention
  • saphenous vein grafts

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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    Papayannis, A. C., Michael, T. T., Yangirova, D., Abdel-Karim, A. R., Kohlhaas, J., Mahmood, A., Addo, T., Haagen, D., Makke, L., Roesle, M., Rangan, B., Banerjee, S., & Brilakis, E. S. (2012). Optical coherence tomography analysis of the stenting of saphenous vein graft (SOS) xience v study: Use of the everolimus-eluting stent in saphenous vein graft lesions. Journal of Invasive Cardiology, 24(8), 390-394.