Optical coherence tomography reflects brain atrophy in multiple sclerosis: A four-year study

Shiv Saidha, Omar Al-Louzi, John N. Ratchford, Pavan Bhargava, Jiwon Oh, Scott D. Newsome, Jerry L. Prince, Dzung Pham, Snehashis Roy, Peter Van Zijl, Laura J. Balcer, Elliot Frohman, Daniel S. Reich, Ciprian Crainiceanu, Peter A. Calabresi

Research output: Contribution to journalArticle

137 Scopus citations

Abstract

Objective The aim of this work was to determine whether atrophy of specific retinal layers and brain substructures are associated over time, in order to further validate the utility of optical coherence tomography (OCT) as an indicator of neuronal tissue damage in patients with multiple sclerosis (MS). Methods Cirrus high-definition OCT (including automated macular segmentation) was performed in 107 MS patients biannually (median follow-up: 46 months). Three-Tesla magnetic resonance imaging brain scans (including brain-substructure volumetrics) were performed annually. Individual-specific rates of change in retinal and brain measures (estimated with linear regression) were correlated, adjusting for age, sex, disease duration, and optic neuritis (ON) history. Results Rates of ganglion cell + inner plexiform layer (GCIP) and whole-brain (r = 0.45; p < 0.001), gray matter (GM; r = 0.37; p < 0.001), white matter (WM; r = 0.28; p = 0.007), and thalamic (r = 0.38; p < 0.001) atrophy were associated. GCIP and whole-brain (as well as GM and WM) atrophy rates were more strongly associated in progressive MS (r = 0.67; p < 0.001) than relapsing-remitting MS (RRMS; r = 0.33; p = 0.007). However, correlation between rates of GCIP and whole-brain (and additionally GM and WM) atrophy in RRMS increased incrementally with step-wise refinement to exclude ON effects; excluding eyes and then patients (to account for a phenotype effect), the correlation increased to 0.45 and 0.60, respectively, consistent with effect modification. In RRMS, lesion accumulation rate was associated with GCIP (r = -0.30; p = 0.02) and inner nuclear layer (r = -0.25; p = 0.04) atrophy rates. Interpretation Over time GCIP atrophy appears to mirror whole-brain, and particularly GM, atrophy, especially in progressive MS, thereby reflecting underlying disease progression. Our findings support OCT for clinical monitoring and as an outcome in investigative trials.

Original languageEnglish (US)
Pages (from-to)801-813
Number of pages13
JournalAnnals of Neurology
Volume78
Issue number5
DOIs
StatePublished - Nov 2015

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Saidha, S., Al-Louzi, O., Ratchford, J. N., Bhargava, P., Oh, J., Newsome, S. D., Prince, J. L., Pham, D., Roy, S., Van Zijl, P., Balcer, L. J., Frohman, E., Reich, D. S., Crainiceanu, C., & Calabresi, P. A. (2015). Optical coherence tomography reflects brain atrophy in multiple sclerosis: A four-year study. Annals of Neurology, 78(5), 801-813. https://doi.org/10.1002/ana.24487