Optical molecular imaging for tumor detection and image-guided surgery

Chensu Wang, Zhaohui Wang, Tian Zhao, Yang Li, Gang Huang, Baran D. Sumer, Jinming Gao

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

We have witnessed rapid development of fluorescence molecular imaging of solid tumors for cancer diagnosis and image-guided surgery in the past decade. Many biomarkers unique to cancer cells or tumor microenvironment, such as cell surface receptors, hypoxia, secreted proteases and extracellular acidosis have been characterized, and can be used to distinguish cancer from normal tissue. A variety of optical imaging probes have been developed to target these biomarkers to improve tumor contrast over the background tissue. Unlike conventional anatomical and molecular imaging technologies, fluorescent imaging method benefits from its safety, high-spatial resolution and real-time capability, and therefore, has become a highly adoptable imaging method for tumor detection and image-guided surgery in clinics. In this review, we summarize recent progress in ‘always-ON’ and stimuli-activatable fluorescent imaging probes, and discuss their potentials in tumor detection and image-guided surgery.

Original languageEnglish (US)
Pages (from-to)62-75
Number of pages14
JournalBiomaterials
Volume157
DOIs
StatePublished - Mar 1 2018

Fingerprint

Computer-Assisted Surgery
Molecular imaging
Molecular Imaging
Optical Imaging
Surgery
Tumors
Imaging techniques
Biomarkers
Neoplasms
Tumor Microenvironment
Tissue
Cellular Microenvironment
Cell Surface Receptors
Acidosis
Fluorescent Dyes
Peptide Hydrolases
Fluorescence
Cells
Technology
Safety

Keywords

  • Cancer diagnosis
  • Cancer molecular imaging
  • Image-guided surgery
  • Stimuli-responsive nanomaterials
  • Tumor microenvironment

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Optical molecular imaging for tumor detection and image-guided surgery. / Wang, Chensu; Wang, Zhaohui; Zhao, Tian; Li, Yang; Huang, Gang; Sumer, Baran D.; Gao, Jinming.

In: Biomaterials, Vol. 157, 01.03.2018, p. 62-75.

Research output: Contribution to journalReview article

Wang, Chensu ; Wang, Zhaohui ; Zhao, Tian ; Li, Yang ; Huang, Gang ; Sumer, Baran D. ; Gao, Jinming. / Optical molecular imaging for tumor detection and image-guided surgery. In: Biomaterials. 2018 ; Vol. 157. pp. 62-75.
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