Orphan Nuclear Receptors as eLiXiRs and FiXeRs of Sterol Metabolism

Research output: Contribution to journalArticle

297 Citations (Scopus)

Abstract

With the recent characterizations of several nuclear orphan receptors, an emerging theme has developed placing these receptors as master regulators of lipid metabolism. The identification of the oxysterol receptors (LXRs) and a bile acid receptor (FXR) has opened up new and exciting fields of research in cholesterol and bile acid metabolism. Understanding the physiological pathways that these receptors regulate and designing pharmaceutical drugs for these receptors may provide alternative treatments for cholesterol and bile acid disorders.

Original languageEnglish (US)
Pages (from-to)37735-37738
Number of pages4
JournalJournal of Biological Chemistry
Volume276
Issue number41
StatePublished - Oct 12 2001

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Orphan Nuclear Receptors
Sterols
Bile Acids and Salts
Metabolism
Cholesterol
Drug Receptors
Lipid Metabolism
Research
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Biochemistry

Cite this

Orphan Nuclear Receptors as eLiXiRs and FiXeRs of Sterol Metabolism. / Lu, Timothy T.; Repa, Joyce J.; Mangelsdorf, David J.

In: Journal of Biological Chemistry, Vol. 276, No. 41, 12.10.2001, p. 37735-37738.

Research output: Contribution to journalArticle

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