Ototopic applications of povidone iodine/dexamethasone in the rat

Karen Pawlowski, Elena Koulich, Charles G. Wright, Peter Roland

Research output: Contribution to journalArticle

Abstract

HYPOTHESIS: Repeated applications of low-concentration povidone iodine (PI) combined with dexamethasone (Dex) through a tympanic membrane ventilation tube will not cause ototoxic changes in the rat. BACKGROUND: Otitis externa (OE) and acute otitis media (AOM) are 2 of the most common otologic disorders requiring outpatient antibiotic treatment. The development of topical treatments that are easy to administer would help to limit systemic exposure to antibiotics in these patients. Topical formulations containing Dex and low-dose PI were designed to provide both antimicrobial and anti-inflammatory effects for the treatment of OE and AOM. Treatment with PI alone has shown mixed results in studies designed to determine PI. Low concentrations of PI combined with Dex should yield less ototoxicity while maintaining effectiveness. METHODS: We performed tympanostomies on rats, inserting a ventilation tube to administer 1% or 2% PI, plus 0.1% Dex over a period of 7 days. Hearing was accessed via auditory brainstem response (ABR) testing over the duration of the study and histologic analysis was performed 15 days after the initial application to determine the effect of administration of PI/Dex on middle and inner ear structures. CONCLUSION: The preparations used in the present investigation were formulated to allow repeated applications to both the external and middle ear, without risk to hearing or equilibrium. Neither of the PI/Dex formulations tested caused pathologic changes in the ear that significantly affected equilibrium, hearing function or morphology.

Original languageEnglish (US)
Pages (from-to)167-174
Number of pages8
JournalOtology and Neurotology
Volume34
Issue number1
DOIs
StatePublished - Jan 2013

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Povidone-Iodine
Dexamethasone
Hearing
Otitis Externa
Otitis Media
Middle Ear
Ventilation
Middle Ear Ventilation
Anti-Bacterial Agents
External Ear
Tympanic Membrane
Brain Stem Auditory Evoked Potentials
Inner Ear
Therapeutics
Ear
Anti-Inflammatory Agents
Outpatients

Keywords

  • Auditory brainstem response
  • Hair cell count
  • Ototoxicity

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Clinical Neurology
  • Sensory Systems
  • Medicine(all)

Cite this

Ototopic applications of povidone iodine/dexamethasone in the rat. / Pawlowski, Karen; Koulich, Elena; Wright, Charles G.; Roland, Peter.

In: Otology and Neurotology, Vol. 34, No. 1, 01.2013, p. 167-174.

Research output: Contribution to journalArticle

Pawlowski, K, Koulich, E, Wright, CG & Roland, P 2013, 'Ototopic applications of povidone iodine/dexamethasone in the rat', Otology and Neurotology, vol. 34, no. 1, pp. 167-174. https://doi.org/10.1097/MAO.0b013e31827a21a2
Pawlowski, Karen ; Koulich, Elena ; Wright, Charles G. ; Roland, Peter. / Ototopic applications of povidone iodine/dexamethasone in the rat. In: Otology and Neurotology. 2013 ; Vol. 34, No. 1. pp. 167-174.
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