Outcome of patients with metastatic chromophobe renal cell carcinoma treated with sunitinib

Daniel Keizman, David Sarid, Jae L. Lee, Avishay Sella, Maya Gottfried, Hans Hammers, Mario A. Eisenberger, Michael A. Carducci, Victoria Sinibaldi, Victoria Neiman, Eli Rosenbaum, Avivit Peer, Avivit Neumann, Wilmosh Mermershtain, Keren Rouvinov, Raanan Berger, Ibrahim Yildiz

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Background. Sunitinib is a standard treatment for metastatic clear cell renal cell carcinoma (mccRCC). Data on its activity in the rare variant of metastatic chromophobe renal cell carcinoma (mchRCC), are limited. We aimed to analyze the activity of sunitinib in a relatively large and homogenous international cohort of mchRCC patients in terms of outcome and comparison with mccRCC. Methods. Records from mchRCC patients treated with first line sunitinib in 10 centers across 4 countries were retrospectively reviewed. Univariate and multivariate analyses of association between clinicopathologic factors and outcome were performed. Subsequently, mchRCC patients were individually matched to mccRCC patients. We compared the clinical benefit rate, progression-free survival (PFS),and overall survival (OS) between the groups. Results. Between 2004 and 2014, 36 patients (median age, 64 years; 47% male) with mchRCC were treated with first-line sunitinib. Seventy-eight percent achieved a clinical benefit (partial response 1 stable disease). Median PFS and OS were 10 and 26 months, respectively. Factors associated with PFS were the Heng risk (hazard ratio [HR], 3.3; p = .03) and pretreatment neutrophil-to-lymphocyte ratio (NLR) >3 (HR, 0.63; p = .02). Factors associated with OS were the Heng risk (HR, 4.1; p = .04), liver metastases (HR, 3.8; p = .03), and pretreatment NLR<3 (HR, 0.55; p =.03).Treatment outcome was not significantly different between mchRCC patients and individually matched mccRCC patients. In mccRCC patients (p value versus mchRCC),72% achieved a clinical benefit (p =.4) and median PFS and OS were 9 (p =.6) and 25 (p =.7)months, respectively. Conclusion. In metastatic chromophobe renal cell carcinoma, sunitinib therapy may be associated with similar outcome and toxicities as in metastatic clear cell renal cell carcinoma. The Heng risk and pretreatment NLR may be associated with PFS and OS.

Original languageEnglish (US)
Pages (from-to)1212-1217
Number of pages6
JournalOncologist
Volume21
Issue number10
DOIs
StatePublished - Oct 1 2016

Keywords

  • Chromophobe type
  • Clear cell type
  • Metastatic renal cell carcinoma
  • Outcome
  • Sunitinib

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Keizman, D., Sarid, D., Lee, J. L., Sella, A., Gottfried, M., Hammers, H., Eisenberger, M. A., Carducci, M. A., Sinibaldi, V., Neiman, V., Rosenbaum, E., Peer, A., Neumann, A., Mermershtain, W., Rouvinov, K., Berger, R., & Yildiz, I. (2016). Outcome of patients with metastatic chromophobe renal cell carcinoma treated with sunitinib. Oncologist, 21(10), 1212-1217. https://doi.org/10.1634/theoncologist.2015-0428