Outcome studies in diabetic nephropathy

Anupama Mohanram, Robert D. Toto

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Outcome studies in diabetic nephropathy have focused on strategies to prevent progression of diabetic nephropathy, the leading cause of ESRD in the United States. Once diabetics develop overt nephropathy, prognosis is poor. Risk factors for diabetic nephropathy are discussed, and include hyperglycemia, hypertension, angiotensin II, proteinuria, dyslipidemia, smoking, and anemia. Major outcomes as well as outcome studies in diabetic nephropathy for patients with microalbuminuria and macroalbuminuria are reviewed. Furthermore, the role of therapy with angiotensin converting enzyme inhibitors, angiotensin II receptor blockers, calcium channel blockers, and mineralocorticoid receptor antagonists as well as selected combination therapy are discussed. Recommendations for therapy with ace inhibitors and angiotensin II receptor blockers are made based on this evidence.

Original languageEnglish (US)
Pages (from-to)255-271
Number of pages17
JournalSeminars in Nephrology
Volume23
Issue number3
StatePublished - May 2003

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Diabetic Nephropathies
Outcome Assessment (Health Care)
Angiotensin Receptor Antagonists
Mineralocorticoid Receptor Antagonists
Calcium Channels
Dyslipidemias
Proteinuria
Angiotensin-Converting Enzyme Inhibitors
Angiotensin II
Hyperglycemia
Chronic Kidney Failure
Anemia
Therapeutics
Smoking
Hypertension

ASJC Scopus subject areas

  • Nephrology

Cite this

Outcome studies in diabetic nephropathy. / Mohanram, Anupama; Toto, Robert D.

In: Seminars in Nephrology, Vol. 23, No. 3, 05.2003, p. 255-271.

Research output: Contribution to journalArticle

Mohanram, A & Toto, RD 2003, 'Outcome studies in diabetic nephropathy', Seminars in Nephrology, vol. 23, no. 3, pp. 255-271.
Mohanram, Anupama ; Toto, Robert D. / Outcome studies in diabetic nephropathy. In: Seminars in Nephrology. 2003 ; Vol. 23, No. 3. pp. 255-271.
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