Outcomes following radiation for cutaneous squamous cell carcinoma of the head and neck: Associations between immune suppression and recurrence

Mona Arbab, Danielle N. Margalit, Roy B. Tishler, Guilherme Rabinowits, Itai M. Pashtan, Bruce B. Borgelt, William Powlis, Clay H. Holdsworth, Laura E. Warren, Jonathan D. Schoenfeld

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: Data evaluating outcomes and patterns of recurrence following radiation therapy (RT) for cutaneous squamous cell carcinoma (cSCC) of the head and neck are limited. Methods: We performed a retrospective analysis of 111 head and neck cSCC patients treated with RT at 4 affiliated institutions. Results: With median follow-up of 7 months, there were 29 (26%) recurrences, 73% of which were nodal (n = 21). Immunosuppression (IS) was the only factor associated with recurrence (47% in IS, 22% in non-IS, P =.04), and also with time to recurrence in multivariate analysis (HR 5.5; P =.03). No factors were associated with recurrence among patients who received definitive RT. The majority of patients who recurred were salvaged with surgery (n = 20, 69%). Conclusion: In a cohort of cSCC treated with radiotherapy, there was an association between IS and increased failure risk. The majority of failures were salvaged surgically.

Original languageEnglish (US)
Pages (from-to)2111-2115
Number of pages5
JournalHead and Neck
Volume41
Issue number7
DOIs
StatePublished - Jul 2019
Externally publishedYes

Keywords

  • cSCC
  • immunosuppression
  • outcome
  • radiation
  • recurrence

ASJC Scopus subject areas

  • Otorhinolaryngology

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