Outcomes of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemoperfusion in Patients with High-Grade, High-Volume Disseminated Mucinous Appendiceal Neoplasms

Patricio M. Polanco, Ying Ding, Jordan M. Knox, Lekshmi Ramalingam, Heather Jones, Melissa E. Hogg, Amer H. Zureikat, Matthew P. Holtzman, James Pingpank, Steven Ahrendt, Herbert J. Zeh, David L. Bartlett, Haroon A. Choudry

Research output: Contribution to journalArticle

12 Scopus citations


Background: High-grade (HG) mucinous appendiceal neoplasms (MAN) have a worse prognosis than low-grade histology. Our objective was to assess the safety and efficacy of cytoreductive surgery with hyperthermic intraperitoneal chemoperfusion (CRS/HIPEC) in patients with high-grade, high-volume (HG–HV) peritoneal metastases in whom the utility of this aggressive approach is controversial. Methods: Prospectively collected perioperative data were compared between patients with peritoneal metastases from HG–HV MAN, defined as simplified peritoneal cancer index (SPCI) ≥12, and those with high-grade, low-volume (HG–LV; SPCI

Original languageEnglish (US)
Pages (from-to)382-390
Number of pages9
JournalAnnals of Surgical Oncology
Issue number2
Publication statusPublished - Feb 1 2016


ASJC Scopus subject areas

  • Surgery
  • Oncology

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