Outcomes of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemoperfusion in Patients with High-Grade, High-Volume Disseminated Mucinous Appendiceal Neoplasms

Patricio M. Polanco, Ying Ding, Jordan M. Knox, Lekshmi Ramalingam, Heather Jones, Melissa E. Hogg, Amer H. Zureikat, Matthew P. Holtzman, James Pingpank, Steven Ahrendt, Herbert J. Zeh, David L. Bartlett, Haroon A. Choudry

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Background: High-grade (HG) mucinous appendiceal neoplasms (MAN) have a worse prognosis than low-grade histology. Our objective was to assess the safety and efficacy of cytoreductive surgery with hyperthermic intraperitoneal chemoperfusion (CRS/HIPEC) in patients with high-grade, high-volume (HG–HV) peritoneal metastases in whom the utility of this aggressive approach is controversial. Methods: Prospectively collected perioperative data were compared between patients with peritoneal metastases from HG–HV MAN, defined as simplified peritoneal cancer index (SPCI) ≥12, and those with high-grade, low-volume (HG–LV; SPCI

Original languageEnglish (US)
Pages (from-to)382-390
Number of pages9
JournalAnnals of Surgical Oncology
Volume23
Issue number2
DOIs
StatePublished - Feb 1 2016

ASJC Scopus subject areas

  • Surgery
  • Oncology

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    Polanco, P. M., Ding, Y., Knox, J. M., Ramalingam, L., Jones, H., Hogg, M. E., Zureikat, A. H., Holtzman, M. P., Pingpank, J., Ahrendt, S., Zeh, H. J., Bartlett, D. L., & Choudry, H. A. (2016). Outcomes of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemoperfusion in Patients with High-Grade, High-Volume Disseminated Mucinous Appendiceal Neoplasms. Annals of Surgical Oncology, 23(2), 382-390. https://doi.org/10.1245/s10434-015-4838-z