Outcomes registry for better informed treatment of atrial fibrillation II: Rationale and design of the ORBIT-AF II registry

Benjamin A. Steinberg, Rosalia G. Blanco, Donna Ollis, Sunghee Kim, Dajuanicia N. Holmes, Peter R. Kowey, Gregg C. Fonarow, Jack Ansell, Bernard Gersh, Alan S. Go, Elaine Hylek, Kenneth W. Mahaffey, Laine Thomas, Paul Chang, Eric D. Peterson, Jonathan P. Piccini

Research output: Contribution to journalArticlepeer-review

Abstract

Background Recent clinical trials have demonstrated the safety and efficacy of several non-vitamin K oral anticoagulants (NOACs) for the treatment of atrial fibrillation (AF). However, there are limited data on their use and outcomes in routine clinical practice, particularly among patients newly diagnosed as having AF and patients with AF recently transitioned to a NOAC. Methods/Design ORBIT-AF II is a multicenter, national registry of patients with AF that is enrolling up to 15,000 newly diagnosed patients with AF and/or those with AF recently transitioned to a NOAC from 300 US outpatient practices. These patients will be followed for up to 2 years, including clinical status, outcomes (major adverse cardiovascular events, bleeding), and management of anticoagulation surrounding bleeding events. In addition, detailed data regarding the use of these agents in and around cardiac procedures, their complications, and management of such complications will be collected. Conclusions The ORBIT-AF II registry will provide valuable insights into the safety and effectiveness of NOACs used in AF in community practice settings.

Original languageEnglish (US)
Pages (from-to)160-167
Number of pages8
JournalAmerican heart journal
Volume168
Issue number2
DOIs
StatePublished - Aug 2014
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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