Oxidative stress and autophagy in cardiovascular homeostasis

Cyndi R. Morales, Zully Pedrozo, Sergio Lavandero, Joseph A Hill

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Significance: Autophagy is an evolutionarily ancient process of intracellular protein and organelle recycling required to maintain cellular homeostasis in the face of a wide variety of stresses. Dysregulation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) leads to oxidative damage. Both autophagy and ROS/RNS serve pathological or adaptive roles within cardiomyocytes, depending on the context. Recent Advances: ROS/RNS and autophagy communicate with each other via both transcriptional and post-translational events. This cross talk, in turn, regulates the structural integrity of cardiomyocytes, promotes proteostasis, and reduces inflammation, events critical to disease pathogenesis. Critical Issues: Dysregulation of either autophagy or redox state has been implicated in many cardiovascular diseases. Cardiomyocytes are rich in mitochondria, which make them particularly sensitive to oxidative damage. Maintenance of mitochondrial homeostasis and elimination of defective mitochondria are each critical to the maintenance of redox homeostasis. Future Directions: The complex interplay between autophagy and oxidative stress underlies a wide range of physiological and pathological events and its elucidation holds promise of potential clinical applicability.

Original languageEnglish (US)
Pages (from-to)507-518
Number of pages12
JournalAntioxidants and Redox Signaling
Volume20
Issue number3
DOIs
StatePublished - Jan 20 2014

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Reactive Nitrogen Species
Oxidative stress
Autophagy
Reactive Oxygen Species
Mitochondria
Oxidative Stress
Homeostasis
Cardiac Myocytes
Oxidation-Reduction
Structural integrity
Maintenance
Recycling
Organelles
Cardiovascular Diseases
Inflammation
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Physiology
  • Clinical Biochemistry

Cite this

Oxidative stress and autophagy in cardiovascular homeostasis. / Morales, Cyndi R.; Pedrozo, Zully; Lavandero, Sergio; Hill, Joseph A.

In: Antioxidants and Redox Signaling, Vol. 20, No. 3, 20.01.2014, p. 507-518.

Research output: Contribution to journalArticle

Morales, Cyndi R. ; Pedrozo, Zully ; Lavandero, Sergio ; Hill, Joseph A. / Oxidative stress and autophagy in cardiovascular homeostasis. In: Antioxidants and Redox Signaling. 2014 ; Vol. 20, No. 3. pp. 507-518.
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